Under physiological conditions, guanine-rich sequences of DNA and RNA can adopt stable and atypical four-stranded helical structures called G-quadruplexes (G4). Such G4 structures have been shown to occur in vivo and to play a role in various processes such as transcription, translation and telomere maintenance. Owing to their high-thermodynamic stability, resolution of G4 structures in vivo re...

The preset response surface methodology (RSM) designs are commonly used in a wide range of process and design optimization applications. Although they offer ease of implementation and good performance, they are not sufficiently adaptive to reduce the required number of experiments and thus are not cost effective for applications with high cost of experimentation. We propose an efficient adaptiv...

The traditional approach to optimizing a product or process using computer simulation is to evaluate the effects of one design parameter at a time. Then after it has been optimized the analyst moves to the next variable. The problem with this approach is that interactions between design factors and second order effects mean that this approach is likely to lead down a blind alley. It will result...

Kojic acid is widely used to inhibit the browning effect of tyrosinase in cosmetic and food industries. In this work, synthesis of kojic monooleate ester (KMO) was carried out using lipase-catalysed esterification of kojic acid and oleic acid in a solvent-free system. Response Surface Methodology (RSM) based on central composite rotatable design (CCRD) was used to optimise the main important re...

In recent years, the fascinating range of Response surface methodology (RSM) applications has captured interest many researchers and engineers worldwide. RSM is entirely based on well-known regression principles variance analysis that enable user to improve, develop optimize process or product under study. An overview theoretical RSM, experimental strategy its tools components, along with pros ...

Coagulation treatment of sago wastewater was studied and laboratory studies were carried out using alum as coagulant. Coagulation treatment conditions were optimised through response surface methodology (RSM). Operational parameters namely dosage of alum (Al [email protected]

Pre-hardened steel (P20) is a widely used material in the production of moulds/dies due to less wear resistance and used for large components. In this study, minimization of surface roughness has been investigated by integrating design of experiment method, Response surface methodology (RSM) and genetic algorithm. To achieve the minimum surface roughness optimal conditions are determined. The e...

Abstract: Response Surface Methodology (RSM) is introduced to optimize the control rod positions in a pressurized water reactor (PWR) core. The widely used 3D-IAEA benchmark problem is selected as the typical PWR core and the neutron flux field is solved. Besides, some additional thermal parameters are assumed to obtain the temperature distribution. Then the total and local entropy production i...

Different endophytes isolated from the seeds of Sophora flavescens were tested for their ability to produce matrine production. Response surface methodology (RSM) was applied to optimize the medium components for the endophytic fungus. Results indicated that endophyte Aspergillus terreus had the ability to produce matrine. The single factor tests demonstrated that potato starch was the best car...

The aim of this study is to obtain optimal decolourization conditions for Acid blue-7 (AB7) wastewater treatment by Ti/TiO2 photoelectrocatalysis using response surface methodology (RSM). On the basis of a three-variable Box-Behnken design (BBD), RSM was used to determine the effect of pH values (ranged from 3.2 to 6), light intensity (ranged from 10 to 20 ×10 2 μW/cm 2 ) and bias potential (ra...