CCS embryonic stem (ES) cells possessing two mutant alleles ( ry 1 r 2 / ry 1 r 2 ) for the skeletal muscle ryanodine receptor (RyR) have been produced and injected subcutaneously into severely compromised immunodeficient mice to produce teratocarcinomas in which Ry 1 R expression is absent. Several primary fibroblast cell lines were isolated and subcloned from one of these tumors that contain ...

BACKGROUND Calcium calmodulin-dependent kinase II (CaMKII) can be more active in patients with left ventricular hypertrophy (LVH), which in turn causes phosphorylation of ryanodine receptors, resulting in inactivation and the instability of intracellular calcium homeostasis. The present study aimed to determine the effect of CaMKII-ryanodine receptor pathway signaling in rabbits with left ventr...