BACKGROUND Triple-negative breast cancer is an aggressive disease with unmet clinical needs. In a phase III study of patients with metastatic triple-negative breast cancer, first-line gemcitabine/carboplatin resulted in a median progression-free survival of 4.6 months. nab-paclitaxel-based regimens (with gemcitabine or carboplatin±bevacizumab) also demonstrated efficacy and safety in first-line...

aims: fatalistic employees take serious risks because they have limited knowledge of risks and accidents, leading them to under estimate the possibility of their occurrence. this research examined the effectiveness of safety training on changing employees’ fatalism with attention to the mediating role of attitude toward safety issues. methods: 204 employees was selected according to the stratif...

The traditional approaches of HCI are essential, but they are unable to cope with the complexity of typical modern interactive devices in the safety critical context of medical devices. We outline some technical approaches, based on simple and “easy to use” formal methods, to improve usability and safety, and show how they scale to typical devices. Specifically: (i) it is easy to visualize beha...

safety issues have always been put forward as one of the major problems and primary concerns in construction industries in many countries. this paper will focus on the impact of safety training on safety climate and its relevant factors in two sites of a construction firm. the health and safety executive (hse) guide to safety climate tool that had been validated in iran was used to determine th...

in this paper, efforts are made to compare the safety of steel moment resistant frames designed according to different editions of the iranian code of practice for seismic resistant design of buildings. also, failure risk of a low and medium height frame which designed for high and low seismicity regions according to three editions of the code are evaluated. first, the testing cases were design...

Accident models are mental that make it possible to understand the causality of adverse events. This research was conducted based on five major objectives: (i) systematically review relevant literature about AcciMap, STAMP, and FRAM synthesize theoretical experimental findings, as well main flows; (ii) examine standalone hybrid applications for modeling leading factors accident behavior sociote...

We study a stochastic lead-time problem motivated by real world global shipping data. Replenishment quantities are generated by the Order-Up-To policy which aims to achieve a strategic availability target. We show that unlike the constant lead-time case, minimum safety stocks do not always lead to minimum costs under stochastic lead-times.

Recent models with liquidity constraints and impatience emphasize that consumers use savings to buffer income fluctuations. When wealth is below an optimal target, consumers try to increase their buffer stock of wealth by saving more, while, if wealth is above target, they increase consumption. This important implication of the buffer stock model of saving has not been subject to direct empiric...

The goal of this study was to carry out singleand multi-aspect ABC analyses in spare parts warehouse. Two cases were considered within the investigations. First case concerned stock with the required safety stock, whereas in the second case, safety stock was neglected. Comparison of the results for both analyses was to show how the level of safety stock impacts on selection of more profitable a...

We describe an implementation of an Oberon0 compiler using the techniques proposed in the CoCoCo project. The compiler is constructed out of a collection of pre-compiled, statically type-checked language-definition fragments written in Haskell.