Abstract The goal of this research was to investigate the ontogenic path followed by somatic embryo from oil palm ( Elaeis guineensis jacq.) with in vitro culture and characterize shoot explants. Explant were injected into a medium for induction calluses, histological analysis perfomed on embryogenic callus embryo. Embryogenic nodular structure still proliferate because cells are meristematic v...

Introduction: Chondrocytes found in articular cartilage are differentiated cells with limited regenerative capacities, and thus limited reparative capability following injury. Current treatments of cartilage damage mostly target pain relief and do not repair damaged articular cartilage. To repair damaged cartilage, transplant of chondrocytes, bone marrow stem cells, and other pluripotent cells ...

Tissue engineered constructs have the potential to respond unmet medical need of treating deep osteochondral defects. However, current tissue engineering strategies struggle in attempt create patterned with biologically distinct functionality. In this work, a developmentally-inspired modular approach is proposed, whereby cartilaginous organoids are used as living building blocks. First, hierarc...

Beta catenin gene can inhibit the chondrogenic differentiation of human adipose tissue derived stem cells, while sex determining region Y-box9 promote cells. However, it is still necessary to study role combination two genes in early The purpose this was investigate whether knockdown and overexpression combined with modification cells could Therefore, divided into four groups or lentivirus vect...

BackgroundAcellular dermal matrix (ADM) allografts are commonly used in the surgical treatment of complex and irreparable rotator cuff tears. Multiple studies report that superior capsule reconstruction (SCR) using ADM has resulted short-term clinical success as assessed via radiographic patient-reported outcomes. However, limited information is available regarding biologic fate these grafts hu...

Articular cartilage repair was followed for one year in skeletally mature dogs after destabilisation by anterior cruciate ligament transection of the stifle joint (CT), abrasion of the inferior medial condyle (ABR) to bleeding bone, or anterior cruciate transection followed by chondral abrasion (CT/ABR). ABR animals formed repair cartilage at the abrasion site (ABR and CT/ABR) at six months as ...

Mesenchymal stem cell (MSC)-based therapies for articular cartilage regeneration are effective mostly due to paracrine signals mediated by extracellular vesicles, especially small vesicles (sEV). However, it is unknown whether dental follicle cell-derived sEV (DFC-sEV) affect in temporomandibular joint osteoarthritis (TMJ-OA). In this study, the effects of DFC-sEV on IL-1β-induced mandibular co...

Thyroid hormone (TH) is essential for bone development. Altered TH levels such as hyperthyroidism, or thyrotoxicosis, results in the early maturation of cartilaginous scaffold long development, which can cause improper ossification. Maternal hyperthyroidism during embryonic development causes neonatal thyrotoxicosis and therefore lead to stunted growth infants. In our avian model induced we inj...