Aims: To detect the presence of human herpes virus 6 (HHV6) and endogenous biotin in paraffin wax embedded and frozen salivary glands. Methods: Two stage indirect and streptavidin-biotin immunoperoxidase techniques were used to visualise the antigens. Results: HHV6 could not be shown in any of the tissues. However, considerable endogenous biotin antigenicity was detected in the glandular elemen...

OBJECTIVES To investigate the expression of IL-34 in labial salivary glands (LSGs) of patients with primary SS (p-SS) and its role in inducing a pro-inflammatory monocyte phenotype. METHODS LSG biopsies were obtained from 20 patients with p-SS and 10 patients with non-Sjögren's sicca syndrome (n-SS). The expression of IL-34, IL-1β, TNF-α, IL-17 and IL-23 was assessed by real-time PCR. IL-34 e...

Sjögren's syndrome is an autoimmune disease characterized by lymphocytic infiltration of the salivary glands. In the NOD mouse, a model for this disease, the development of lymphocytic infiltrates in the salivary glands is preceded by an accumulation of dendritic cells (DC). Given the key importance of DC in regulating the immune response, we characterized the DC isolated from NOD salivary glan...

AIM To analyze and compare the expression of MTNR1A receptor in normal and pathological major and minor salivary glands. MATERIALS AND METHODS Twenty samples of major and minor salivary glands and 10 with Warthin's tumor were studied. Expression of the MTNR1A receptor (goat polyclonal antibody raised against a peptide mapping at the N-terminus of MEL-1A R of human origin) was analyzed. RESU...

OBJECTIVE To investigate the effect of botulinum toxin type A (BTXA) on drooling and the morphologic change of the salivary gland in patients with cerebral palsy. METHOD Eight cerebral palsy patients suffering from severe drooling participated in this study. BTXA was injected into both submandibular and parotid glands under intravenous sedation and with ultrasound guidance (1 unit/gland/kg: m...

Head and neck cancer patients treated with irradiation often present irreversible salivary gland hypofunction for which no conventional treatment exists. We recently showed that recombinant neurturin, a neurotrophic factor, improves epithelial regeneration of mouse salivary glands in ex vivo culture after irradiation by reducing apoptosis of parasympathetic neurons. Parasympathetic innervation ...

ABSTRACT Introduction: Pleomorphic adenoma is the most common tumor of the salivary gland. The tumor most commonly arises in the parotid or submandibular salivary glands. Infrequently, it arises from minor salivary glands. Minor salivary gland tumors are mostly malignant. Case Report: We report four cases of pleomorphic adenoma of hard palate. All four cases range from 30–45 years. All were ben...

Using a panel of synthetic oligosaccharides attached to a polyacrylamide carrier, the epitope of monoclonal antibody F2, evoked to high M(r) salivary mucins, was mapped to the SO3-3Gal beta 1-3GlcNAc- moeity of the sulfo-Le(a) antigen. Using immunochemical techniques, the expression of the F2-epitope was investigated in a number of different isolated human mucin species, as well as in human and...

A molecular survey was performed for identification Theileria spp in sheep and ticks during from 2010-2011 in Fasa and Kazeroun areas, Fars province, Iran. A total of 100 sheep from different flocks were clinically examined and blood samples with ixodid ticks collected. The prepared blood smears from capillary vein of ear were stained with giemsa methods and examined by using light microscope. ...

Babesiosis is an important tickborne disease in the sheep of Iran. OBJECTIVES: A molecular study was carried out in North Khorasan province, Iran in 2010-2011, designed to identify Babesia spp. infection of both sheep and ticks. METHODS: Ninety sheep from different flocks were clinically examined and blood samples were collected with ixodid  ticks . The collected ticks were separated into 82 ti...