The. inbred NZB/BL mouse has been shown by Bielschowsky, Helyer, and Howie (1959) to develop auto-immune haemolytic anaemia spontaneously, and this disorder has been considered to be genetically determined (Holmes and Burnet, 1966). Burnet and Holmes (1962) described a characteristic thymic change in this 'auto-immune' strain of mice; and certain renal lesions have been noted (Holmes and Burnet...

Since the introduction of the "self-marker" hypothesis of antihody production by Burnet and Fenner (1949) and the experiments of Billingham, Brent and Medawar (1953) on the production of actively acquired tolerance in mice to skin homografts from a different strain, there has been a great deal of interest in the immunological behaviour of animals exposed in utero to a variety of antigens. Burne...

Romance has for some time been a term of dubious associations. In the seventeenth century, Thomas Burnet decried those critics who would call his Theory of the Earth a ‘Philosophik Romance’; in the eighteenth century, Buffon did just that, and before too long, his theory of the Earth was the subject of the same epithet. By 1780, the early days of the era of Romanticism (so early that it was not...

ZYM-201 is a methyl ester of triterpenoid glycoside from Sanguisorba officinalis which has been used for treatment of inflammatory and metabolic diseases. In this study, immunomodulatory effects of ZYM-201 on B cells were examined in vitro and in vivo. When splenocytes were activated with lipopolysaccharide (LPS), the major population which had shown an increase in cell numbers was B cells. How...