The serine/threonine phosphatase protein phosphatase 2A (PP2A) plays an essential role in many aspects of cellular functions and has been shown to be an important tumor suppressor. The core enzyme of PP2A comprises a 65 kDa scaffolding subunit and a 36 kDa catalytic subunit. Here we report the crystal structures of the PP2A core enzyme bound to two of its inhibitors, the tumor-inducing agents o...

In this paper, we incorporate scaffolding and change of tutor context within the Bayesian Knowledge Tracing (BKT) framework to track students’ developing inquiry skills. These skills are demonstrated as students experiment within interactive simulations for two science topics. Our aim is twofold. First, we desire to improve the models’ predictive performance by adding these factors. Second, we ...

Heterotrimeric G proteins are ubiquitous signaling partners of seven transmembrane-domain G-protein-coupled receptors (GPCRs), the largest (and most important pharmacologically) receptor family in mammals. A number of scaffolding proteins have been identified that regulate various facets of GPCR signaling. In this review, we summarize current knowledge concerning those scaffolding proteins that...

Concept maps have been widely used in educational contexts to facilitate meaningful learning. Recent research has examined how concept mapping tools assist students in summarizing, relating, and organizing concepts. Our goal is to explore how personalized scaffolding can be applied to concept map construction. We provide personalized scaffolding in the form of an adaptive expert skeleton map ba...

This paper presents a process-oriented case study of successes and failures in collaborative inquiry. The interactions of pairs were recorded and transcribed while they were engaged in learning activities, mediated by agent-based NetLogo electricity models. Transcripts of learner interactions were coded for engagements in science inquiry. The purpose of this paper is to articulate the dynamics ...

Scaffolding errors and incorrect repeat disambiguation during de novo assembly can result in large scale misassemblies in draft genomes. Nextera mate pair sequencing data provide additional information to resolve assembly ambiguities during scaffolding. Here, we introduce NxRepair, an open source toolkit for error correction in de novo assemblies that uses Nextera mate pair libraries to identif...

One of the major challenges in the field of tissue engineering is the production of scaffolding in nano-scale. The study of structural-functional connections in pathological and normal tissues with biologically active alternatives or engineered materials has been developed. Extracellular Matrix (ECM) is a suitable environment consisting of gelatin, elastin and collagen types I, II and III, etc....

Abstract The role of EFL lecturers’ first language (L1) in the EFL courses has been an ongoing debate. A monolingual approach to EFL suggests that the use of the target language solely in foreign language (FL) classroom improves learning of the target language. Accordingly, the purpose of the present study was to investigate the attitude of Iranian lecturers and EFL learners towards using L1 as...

A pivotal issue in research on writing concerns whether the knowledge of how genres are constructed and learned in one discipline/genre can be transferred to other contexts, genres, and disciplines. Yet, studies conducted so far have not presented a unified and complete view of how various writing instructional techniques can result in transferability. This study examined the effect of structur...

This study examines the effectiveness of scaffolding in context Majmaah University EFL. It does so by exploring attitudes and perceptions a randomly selected group (30) EFL instructors various backgrounds degrees. Theoretically, it is informed medley relevant theories approaches Vygotsky’s Sociocultural Theory Learning, Bakhtin's Dialogism Habermas’ Communicative Rationality. Methodologically, ...