The design of bioactive scaffolds with improved mechanical and biological properties is an important topic of research. This paper investigates the use of polymer-ceramic composite scaffolds for bone tissue engineering. Different ceramic materials (hydroxyapatite (HA) and β-tri-calcium phosphate (TCP)) were mixed with poly-ε-caprolactone (PCL). Scaffolds with different material compositions wer...

Highly porous poly (ϵ-caprolactone) microfiber scaffolds can be fabricated using electrospinning for tissue engineering applications. Melt electrospinning produces such scaffolds by direct deposition of a polymer melt instead of dissolving the polymer in a solvent as performed during solution electrospinning. The objective of this study was to investigate the significant parameters associated w...

This paper reports the fabrication of scaffolds consisting of radially aligned poly(ε-caprolactone) nanofibers by utilizing a collector composed of a central point electrode and a peripheral ring electrode. This novel class of scaffolds was able to present nanoscale topographic cues to cultured cells, directing and enhancing their migration from the periphery to the center. We also established ...

The aim of this study was to compare the effect of implantation site (i.e., subcutaneous, SQ vs. intramuscular, IM) on bone forming capacity of cell-based and growth factor-based scaffolds in athymic nude rats after an implantation period of 8 weeks. Cell-based scaffolds consisted of porous hydroxyapatite/tricalcium phosphate (HA/TCP) scaffolds seeded with either human adipose tissue-derived me...

Purpose: The purpose of this study is to:Highlight the difficulty using a bone (autologous, allograft) in tissue engineering.Present different substitutes (of natural or synthetic origin used guided regeneration alone combination.Describe materials and 3D printing techniques scaffolds for regeneration. Material And Methods: Research to Scaffolds its use dentistry between January 2012 December 2...

Abstract Due to their mulitpotency, Mesenchymal stem cells (MSCs), have the ability to proliferate and differentiate into multiple mesodermal tissues. The aim of this study was to isolate MSCs from human Umbilical Cord (hUCMSCs) to determine their osteogenic potential on nanofibrous scaffolds. To this end, Poly (L-lactic acid) (PLLA)/Nano hydroxyapatite (HA) composite nanofibrous scaffolds were...

The present study set out to delineate to what extentfive intermediate learners engaged in structuring and problematizing scaffolding in two writing tasks. The study aimed at illuminating how the participants engaged with structuring and problematizing scaffolds cognitively, behaviorally, and affectively.  Learners’ written essays, think-aloud protocols, and interviews shaped the data sources w...

Background: Through combining two synthetic and natural polymers, scaffolds can be developed for tissue engineering and regenerative medicine purposes. Methods: In this work, carboxymethyl chitosan (CMC; 20%) was grafted to Polycaprolactone (PCL) nanofibers using the cold atmospheric plasma of helium. The PCL scaffolds were exposed to CAP, and functional groups were developed on the PCL surface...

In recent years, nanocomposite scaffolds made of bioactive polymers have found multiple applications in bone tissue engineering. In this study composite nanofibrous structure of gelatin (Gel)/chitosan (Cs)-polycaprolactone (PCL) containing hydroxyapatite (HA) were fabricated using co-electrospinning process. To assay the biocompatibility and bioactivity of electrospun nanocomposite scaffolds, t...

Recently, fibrin sealants that typically contain supra physiological concentrations of fibrinogen and thrombin have been investigated as matrices to facilitate the delivery of cells within biodegradable scaffolds for tissue engineering applications. It is well known from in vitro experiments that the thrombin concentration present during fibrin polymerization influences the structural propertie...