Avenue, Urbana, Illinbis 61801 A qualitative physics which captures the depth and breadth of an engineer’s knowledge will be orders of magnitude larger than the models of today’s qualitative physics. To build and use such models effectively requires explicit modeIing assumptions to manage complexity. This, in turn, gives rise to the problem of selecting the right qualitative model for some purp...

Mammalian cell culture technology has improved so rapidly over the last few years that it is now commonplace to produce multi-kilogram quantities of therapeutic monoclonal antibodies in a single batch. Purification processes need to be scaled-up to match the improved upstream productivity. In this chapter key practical issues and approaches to the scale-up of monoclonal antibody purification pr...