Despite widespread advances in coronary heart disease (CHD) treatment and the growing use of implantable cardioverter-defibrillators (ICDs), sudden cardiac death (SCD) remains a major cause of CHD death in the United States,1 and identification of patients at risk for SCD remains a challenge. Left ventricular ejection fraction (LVEF) has been found to be the strongest independent predictor of S...

We describe a case of an otherwise healthy 48-year-old man who survived aborted sudden cardiac death (SCD). His ECG showed ST segment elevation in inferior leads, therefore an acute coronary syndrome was suspected. However, serial troponin T and CPK-MB were negative, echocardiogram was unremarkable and exercise test was negative. On the basis of electrophysiological study, positive ajmaline tes...

Despite enormous progress over the past few decades in reducing deaths from cardiovascular disease, the ability to identify patients at risk for sudden cardiac death (SCD) remains a challenge. SCD accounts for about 350,000 deaths annually in the United States (1). Most SCDs are from ventricular arrhythmias—ventricular tachycardia and ventricular fibrillation (VT/VF)— and the means to effective...

Although effective low-cost interventions exist, child mortality attributable to sickle cell disease (SCD) remains high in low-resource areas due, in large part, to the lack of accessible diagnostic methods. The presence of dense (ρ > 1.120 g/cm(3)) cells is characteristic of SCD. The fluid, self-assembling step-gradients in density created by aqueous multiphase systems (AMPSs) identifies SCD b...

OBJECTIVE: Sickle cell disease (SCD) conveys a high risk of neuropsychological impairment due to chronic anemia, hypoxemia, cerebrovascular ischemia and stroke, in addition to causing pain and other biomedical complications. Few families accessed neuropsychological testing via the traditional referral system. In this paper, we describe a successful alternative strategy for addressing cognitive ...

The aim of the study was to evaluate the craniofacial morphology in Caucasian patients with sickle cell disease (SCD) by comparing them with a healthy group paired for gender and age, by means of lateral cephalometric radiographs. Thirty-six Sicilian patients with SCD (17 females and 19 males), including 14 beta(s)beta(s) (mean age 28 +/- 5.9 years), 13 beta(s)beta(0 th) (mean age 27.5 +/- 8 ye...

Sickle cell disease (SCD) is common throughoutmuchof sub-SaharanAfrica, affecting up to 3% of births in some parts of the continent. Nevertheless, it remains a low priority formany health ministries. The most common form of SCD is caused by homozygosity for the -globin S gene mutation (SS disease). It is widely believed that this condition is associated with very high child mortality, but relia...

Background Sickle cell disease (SCD) is a major public health concern in tribal community not only in Gujarat but also globally. Gujarat, a western state of India, has 89.12 lakh tribal populations and is expected to have at least 9,00,000 sickle cell trait and 70,000 SCD patients. The aim of the present review is to document the prevalence of SCD in various communities and various screening me...

Cerebrovascular lesions are frequently observed in patients with sickle-cell disease (SCD) and these structural lesions are preceded by insidious perfusion deficits. Our aim was to investigate the presence of brain perfusion deficits in neurologically asymptomatic SCD patients, especially affecting microvessels. For this study, 42 SCD patients [33 sickle-cell anemia (HbSS), 6 sickle hemoglobin ...

Nigeria accounts for 50% of sickle cell disease (SCD) births worldwide and about 2.3% of her population suffers from SCD with 25% of Nigerians being healthy carriers. This study determined the knowledge, attitude and practice of youths in Yaba, Nigeria towards pre-marital genetic counseling. Data was collected using a questionnaire containing both open ended and closed ended questions. The ques...