BACKGROUND Effectiveness of antipsychotics in treating emotional and cognitive deficits in schizophrenia still remains controversial. The aim of our study was to assess emotional and cognitive functioning in schizophrenic inpatients currently treated with typical antipsychotics (perphenazine, perazine, fluphenazine, and haloperidol) and in another group of schizophrenic inpatients currently on ...

BACKGROUND We assessed the suitability of event-related potential frontal and temporoparietal P300 changes as intermediate phenotypes in genetic studies of schizophrenia. We applied a principal component analysis approach based on the notion that P300 abnormalities in siblings of schizophrenic patients may involve a widespread network of relatively weak cortical generators and because an earlie...

Smooth pursuit eye movements (SPEM) has been reported to be abnormal in schizophrenic patients. 30 schizophrenic patients and 15 normal subjects were examined for the quality of their smooth pursuit performance. 73.33% of the schizophrenics and 40% of the normal subjects had 'impaired' pursuit performance. The significance of the findings has been discussed.