Tau, a primary component of microtubule-associated protein, promotes microtubule assembly and/or disassembly and maintains the stability of the microtubule structure. Although the importance of tau in neurodegenerative diseases has been well demonstrated, whether tau is involved in peripheral nerve regeneration remains unknown. In the current study, we obtained sciatic nerve tissue from adult r...

With great interest, we read the article by Prakash et al, entitled “Sciatic nerve division: a cadaver study in the Indian population and review of the literature”.(1) A total of 86 inferior extremities were dissected in order to expose the sciatic nerve, including its division into the tibial and common peroneal nerves. First, we would like to commend the authors for emphasising the issue of s...

Sciatic nerve injury is a common disease of peripheral nerve in clinic. After nerve injury, there are many dysfunctions in motoneurons and muscles following regeneration. Previous studies mostly investigated the aspects related to the injured nerve, and the effect on the recurrent inhibition (RI) pathway of spine following regeneration was not fully understood. Following reinnervation after tem...

Intramuscular drug injection in the gluteal region is often the most frequent cause of sciatic nerve injury in preterm newborns. Local anatomic variation is one of the predisposing causes of iatrogenic sciatic nerve injury. The aim of this morphological study was to assess the relationship of sciatic nerve with the piriformis muscle and to elucidate variations of fusion of piriformis with neigh...

We investigated the effect of leg position on the depth of the sciatic nerve and quality of ultrasound images taken at the proximal and mid-thigh level. Twenty-one volunteers with average body mass index were recruited to represent the younger population receiving sciatic nerve blocks for sports injury surgery. The volunteers were placed in the lateral position, with the hip flexed and with the...

BACKGROUND Sciatica without evidence of lumbosacral root compression is often attributed to piriformis syndrome. However, specific diagnostic tools have not been available to demonstrate sciatic nerve entrapment by the piriformis muscle. OBJECTIVE To evaluate the use of magnetic resonance (MR) neurography in identifying abnormalities of the sciatic nerve in patients with unexplained sciatica....

BACKGROUND AND OBJECTIVES Unilateral spinal anesthesia has advantages when used in outpatient basis. The objective of the present study was to compare unilateral spinal anesthesia with combined sciatic-femoral nerve block in unilateral orthopedic surgeries in outpatients. METHODS Sixty patients were randomly divided into two groups of 30 patients to receive 6 mg of hyperbaric or hypobaric bup...

BACKGROUND AND OBJECTIVES Recently, administration of sciatic nerve block has been revised due to the potential benefit for postoperative analgesia and patient satisfaction after the advent of ultrasound. The aim of this study was to describe the anatomical relations of the sciatic nerve in the popliteal fossa to determine the optimal distance the needle must be positioned in order to realize t...