Sorbitol is converted to fructose in Rosaceae species by SORBITOL DEHYDROGENASE (SDH, EC 1.1.1.14), especially in sink organs. SDH has also been found in non-Rosaceae species and here we show that the protein encoded by At5g51970 in Arabidopsis thaliana (L.) Heynh. possesses the molecular characteristics of an SDH. Using a green fluorescent protein-tagged version and anti-SDH antisera, we deter...

Carney-Stratakis syndrome, an inherited condition predisposing affected individuals to gastrointestinal stromal tumor (GIST) and paraganglioma, is caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C, or D, leading to dysfunction of complex II of the electron transport chain. We evaluated the role of defective cellular respiration in sporadic GIST lacking mutations in KIT...

INTRODUCTION Subdural hematoma (SDH) is a well described risk factor in the development of Status Epilepticus (SE), however the epidemiology of SE after SDH is unknown. In this study, we sought to determine the epidemiology of SE, the prevalence of risk factors, and impact on hospital mortality using a large administrative dataset. METHODS Data was derived from the Nationwide Inpatient Sample...

BACKGROUND AND PURPOSE Subdural hemorrhage (SDH) is often associated with infants experiencing nonaccidental injury (NAI). A study of the appearance and natural evolution of these birth-related hemorrhages, particularly SDH, is important in the forensic evaluation of NAI. The purpose of this study was to determine the normal incidence, size, distribution, and natural history of SDH in asymptoma...

Shaken baby syndrome (SBS) is a form of child abuse that can cause significant head injuries, of which subdural hematoma (SDH) is the most common manifestation. We report the MRI findings of chronic SDH in three cases of SBS, involving two-, three- and eight-month-old babies. The SDH signal was mostly low on T1-weighted images and high on T2-weighted images, suggesting chronic SDH. In chronic S...

To date, the consequences of succinate dehydrogenase (SDH) impairment on overall mitochondrial functions are still obscure. In this study, we evaluated SDH activity and expression and mitochondrial homeostasis in 57 tissue samples of pheochromocytoma (PHEO)/paraganglioma (PGL) obtained from patients genotyped for PHEO/PGL susceptibility genes. The resulted SDH activity and content always decrea...

This article discusses Ethernet over PDH over SONET/SDH (EoPoS), EoPDH, and Ethernet over SONET/SDH. The emergence in the 1990s and the history of Next-Generation SONET/SDH (NGS) equipment are described. The article explains that NGS could not provide ubiquitous interoperability with legacy systems, and thus was not universally implemented. Finally, today's emerging technology, Ethernet over PD...

Subarachnoid hemorrhage (SAH) almost invariably develops following the rupture of a cerebral aneurysm, and is often complicated by intracerebral hematoma (ICH) and intraventricular hematoma. Subdural hematoma (SDH) can occur rarely. Reported incidence of SDH associated with aneurysm bleed varies from 0.5 to 7.9%.1,2 In most cases SDH is associated with SAH and/or ICH. Intracranial aneurysmal ru...

Cowden syndrome (CS), a Mendelian autosomal-dominant disorder, predisposes to breast, thyroid and other cancers. Germline mutations in phosphatase and tensin homolog (PTEN) have been recently reported in 23% of a large series of classic CS. Here, we validated our small (n = 10) pilot study in a large patient series that germline variations in succinate dehydrogenase genes (SDHx) occur in 8% (49...

background: there are several conflicting conceptual models to explain social determinants of health (sdh) as responsible for most health inequalities. this study aimed to present these models in historical perspective and provide main component of sdh models as an ses indicators. methods: this was a narrative study using international databases to retrieve literature dealing with conceptual mo...