Purpose: To study the phytochemical composition of Siphonochalina siphonella sponge from the western coast of the Red Sea and to evaluate the isolates for possible in vitro cytotoxic, antibacterial and antiviral activities. Methods: The compounds obtained were isolated and purified by different chromatographic means. Their structures were established by means of spectral analysis including 1D H...

PURPOSE Dolastatins are a group of structurally unique peptides originally isolated from a sea hare, Dolabella auricularia, which seem to inhibit tubulin polymerization and mitosis. Tasidotin hydrochloride (tasidotin), a novel synthetic analogue of dolastatin 15, is evaluated in preclinical models of pediatric tumors. EXPERIMENTAL DESIGN The cytotoxicity of tasidotin was evaluated in a panel ...

The stability of marine ice sheets grounded on beds that slope upwards in the overall direction of flow is investigated numerically in two horizontal dimensions. We give examples of stable grounding lines on such retrograde slopes illustrating that marine ice sheets are not unconditionally unstable in two horizontal dimensions. Retrograde bed slopes at the grounding lines of marine ice sheets, ...

Japan's Hokuriku region, near the Sea of Japan, typically experiences heavy snowfall; however, Niigata City, largest city on Japan side, lower levels snowfall than neighbouring cities. This study investigates snow-shadow effect Sado Island in located 45 km away leeward. Statistical analysis long-term radar data for 10 winters showed that effects plain occurred 151 (80%) 188 cases, during which ...

Four new species of the coral-associated gobiid genus Gobiodon were discovered in the Red Sea. Although several of these species are common not only in the Red Sea but also in the Indian and western Pacific Ocean, they have not been described before. Detailed descriptions of the four species are based on morphological and molecular genetic (mitochondrial 12s and 16s rRNA) investigations. The ne...

Power oscillations are a growing concern among power system operators worldwide. Traditionally, the main countermeasure against dangerous power oscillations has been the installation of power system stabilizers (PSS). Essentially, the potential for inter-area power oscillations depends on the strength of the tie lines between different areas and the load on the ties. From a European perspective...

In November 1998 participants of a tuna longline stakeholders meeting recommended that a technical officer be appointed to the domestic tuna fleet in order to meet with fishermen and provide assistance, advice and information on how to minimise seabird bycatch in the pelagic longline industry. This position initially commenced in March 1999, and continued until September 1999. During the course...

Geological evolution of the Indian and Pacific Ocean basins, including the Tethys Sea, is relevant to the evolution and distribution of Indo-Pacific freshwater fishes. Area cladograms derived from phylogenetic analyses of atherinomorph fishes are compared, in part, with those for plant bugs, cicadas and bats. Geologically and biologically composite islands in the Indo-Australian archipelago suc...

In this paper, the mooring dynamic loads and the motion responses of a large container ship in irregular waves with steady wind and current is investigated based on the commercial software AQWA. Comparisons between the time-history motion responses of a large container ship and the change of the mooring line tension in three different cases, non-mooring case, V-type mooring case and I-type moor...