Abstract Thyroid cancer is the most common endocrine malignancy and one of fastest growing cancers in United States. Follicular thyroid carcinoma (FTC) represents second form diagnosed US often tied to mutations RAS protein family MAP kinase pathway. In addition driver mutations, FTC characterized by a unique tumor microenvironment (TME) composed cellular non-cellular components that impact tum...

results there were 39 cases with lymph node metastasis in 59 malignant tumors, and 0 cases in 6 benign follicular type tumors. the staining scores by jt-95 of the 39 tumors with lymph node metastasis were 5+ in eight cases and 6+ in 31 cases. on the other hand, the scores of 20 malignant tumors without lymph node metastasis were < 4+ in all of the cases. in the co-cultured assay, numerous adhes...

Quorum sensing (QS) is a process that enables bacteria to communicate using secreted small pheromone-like signaling molecules called autoinducers (AIs). This population of regulate gene expression collectively. These quorum systems regulates biofilm formation, virulence factors expression, bioluminescence, motility patterns, exopolysaccharide production, antifungal or antibiotic endoglucanase p...

Background: Preeclampsia is one of the most common complications of pregnancy that occurs after the 20th weeks of pregnancy.The pathophysiology of this disease is not exactly known. Transforming Growth Factor-beta (TGF-β) and Nitric Oxide (NO) are thekey regulatory factors secreted by Mesenchymal stem Cells (MSCs). Objectives: The aim of the present study was to evaluate the TGF-β and NO secret...

Disease relapse is the greatest cause of treatment failure in paediatric B-cell acute lymphoblastic leukaemia (B-ALL). Current risk stratifications fail to capture all patients at relapse. Herein, we used a machine-learning approach identify B-ALL blast-secreted factors that are associated with poor survival outcomes. Using this approach, identified two-gene expression signature (CKLF and IL1B)...

The expression of heterologous secreted proteins in Escherichia coli is widely employed for laboratory and preparative purposes. Thanks to advances in expression technologies over the past 25 years, many mammalian proteins can now be produced routinely in secreted form with yields in the gram/litre scale. Nonetheless, ensuring efficient secretion across the inner membrane, and preventing proteo...

 Objective(s):  Being secreted by the pineal gland, melatonin induces cell proliferation in normal cells and induced apoptosis in cancer cells. The purpose of this study was to investigate effects of melatonin on main components and the expression of apoptotic genes in vitrified-thawed testicular germ cells of 6- day–old mice.  Materials and Methods: Testes of neonate Balb/c mice were vitrifie...

Background: Tuberculosis is a disease with high morbidity, caused mainly by Mycobaterium tuberculosis (M.tb.). DNA vaccines show a promising future due to their unique advantages over conventional methods. The early-secreted antigen target (ESAT)-6 and culture filtrate protein (CFP)-10 of M.tb. antigens have been identified as vaccine candidates against Mycobacteria and used as subunit vaccines...

Background: The methylotrophic yeast Pichia pastoris is an appealing production host for a variety of recombinant, including biologics. In this sense, various genetic- and non-genetic-based techniques have been implemented to improve the production efficiency of this expression platform. Los1 (loss of supression) encodes a non-essential nuclear tRNA exporter in Saccharomyces cerevisiae, which i...

The CLE family (CLAVATA3/embryo surrounding region-related), a class of small secreted proteins, play important roles in plant development and stress responses. Members the have been characterized number species, including Arabidopsis rice. However, limited information is available about peptides tobacco (Nicotiana tabacum) related Nicotiana species. Here we report identification 84 members thr...