Virosecurinine is a major alkaloid of the plant Securinega suffruticosa and has been found to be a potent agent in inducing the differentiation of cancer cells. The present study aimed to investigate the antitumor effects of virosecurinine by inducing the apoptosis of leukemic K562 cells and to examine the underlying mechanisms. K562 cells were treated with different concentrations of virosecur...

ETHNOPHARMACOLOGICAL RELEVANCE In Kenya, 22 million people are at risk of malaria, 70% of them are in rural areas and most of these people use traditional plant based medicines to treat malaria. The aim of the study was to escalate documentation, from an earlier study of medicinal plants, traditionally used to treat malaria by the Digo community of Kwale County, taking cognizance of their pharm...

We have recently developed a method for the analysis of toxins in single specimens of the mush­ room Amanita phalloides (Fr.) Seer.1. Separation of the different toxins was achieved by column chro­ matography, on Sephadex LH20 in water, of a methanolic extract of fresh or dried mushrooms, followed by further purification on thinlayers of silica gel, spectrophotometric evaluation, and, final­ ly...

Dilemma Zone Design as a Marginal Cost-Benefit Problem" (2007). One control objective at high-speed isolated intersections is to provide safe phase transition by minimizing the occurrence of high-speed vehicles in the dilemma zone before the phase is terminated. An upper limit for extending the green (maximum green time) is used to avoid an indefinite extension of the main-street green. Current...