creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. creatine supplements have shown beneficial effects on neurological disorders including parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, alzheimer's disease and stroke. however, the potential benefits of creatine for pati...

background and objectives: most antiepileptic drugs that are commonly being used in the clinic have a wide range of unwanted side effects; while some species of pistachioshave been used in the traditional medicine to treat epilepsy. the aim of the present study was to investigate the anticonvulsant effects of the hydroalcoholic extract of pistacia vera l. in pentylenetetrazole (ptz)-induced che...

abstract background: seizure is a frequent and important finding in the field of clinical toxicology. almost all poisons and drugs can produce seizure. we have evaluated frequency and complications of drug-induced seizure in present study. methods: the present descriptive cross-sectional study was done on patients who were referred to baharloo hospital, tehran, iran, that had developed seizure ...

pyridoxine dependent seizure have been recornized as a rare and important cause of intractable seizure in neonates and infants.prompt diagnosis and treatment can stop and prevent these seizure and consequential developmental disabilities.furthermore it can eliminate the unnecessary administration of anticonvulsant medications and thier side effects.the paitient was 7 months old infant who was r...

There is growing evidence that antitumor treatment contributes to better seizure control in low-grade glioma patients. We performed a systematic review of the current literature on seizure outcome after radiotherapy and chemotherapy and evaluated the association between seizure outcome and radiological response. Twenty-four studies were available, of which 10 described seizure outcome after rad...

Introduction: Epilepsy is the second most common nervous disorder after brain strok. In spite of present anticonvulsant drugs, researchers need to search for drugs with better efficacy and less side effects. Medicinal plants with various natural components so that different properties are suitable field for investigation. In this study, anticonvulsant effect of Lavandula vera DC. and Cuscuta ep...

Introduction: This study was designed to investigate the possible anticonvulsant effect of acute administration of an aqueous extract of flowers of Alcea aucheri (EFA) in a seizure model. Methods: Seizures were induced in male adult Swiss mice by administration of pentylenetetrazol (PTZ) or Maximal Electroshock (MES). Mice were randomly subjected to receive saline, EFA (8.75-175 mg.kg-1), or d...

GABAergic interneurons play critical roles in seizures, but it remains unknown whether these vary across interneuron subtypes or evolve during a seizure. This uncertainty stems from the unpredictable timing of seizures in most models, which limits neuronal imaging or manipulations around the seizure onset. Here, we describe a mouse model for optogenetic seizure induction. Combining this with ca...

INTRODUCTION Juvenile myoclonic epilepsy (JME) is a genetic generalized epilepsy syndrome. Under appropriate antiepileptic drugs (AED) up to 85% of patients become seizure-free, but many may have a relapse after AED withdrawal. METHODS We retrospectively studied 242 patients with JME at the Department of Neurology, Medical University Innsbruck, Austria (1975-2006). We analyzed age at seizure ...

Objective(s): Scientific interest in potential mobile phone impact on human brain and performance has significantly increased in recent years. The present study was designed to evaluate the effects of mobile phone radiation on seizure threshold in mice. Materials and methods:BALB/c male mice were randomly divided into three groups: control, acute, and chronic mobile phone radiation for 30, 60, ...