Studies have indicated that the aggregation of activated platelets with cancer cells facilitates tumor metastasis; the adhesion molecule P-selectin may be an important mediator of this process, but the detailed mechanism is unclear. In the current study, we established a B16F10 (B16) cell metastatic model in P-selectin knockout (P-sel-/-) mice to determine the effect of P-selectin-mediated plat...

the diagnostic process for subepithelial lesions (SELs). Location of the mass within the gut wall, internal echogenicity, outer margins of the mass, and its relation to extramural structures can all be determined using EUS. Careful examination may provide a definitive diagnosis such as cyst or lipoma when these characteristic EUS findings are observed. Alternately, narrowing the differential di...

BACKGROUND/AIMS Oxidative DNA damage by reactive oxygen species is involved in the process of liver carcinogenesis. To test the hypothesis that a remedy containing Scutellaria baicalensis Georgi (Sb) and Bupleurum scorzonerifolfium Willd (Bs) (Sb/Bs remedy) modulates hepatic neoplastic growth, BOP (N-nitrosobis(2-oxopropyl)amine)-induced liver cancers in hamsters were established. METHODS Par...

OBJECTIVE The objectives of this study were to determine whether hypercholesterolemia promotes platelet-endothelial cell (P/E) adhesion in murine postcapillary venules and define the contributions of endothelial or platelet associated P-selection to hypercholesterolemia-induced P/E interactions. METHODS AND RESULTS Wild-type (WT) or P-selectin deficient (P-sel-/-) platelets were isolated and ...

The Notch signaling pathway is essential in many cell fate decisions in invertebrates as well as in vertebrates. After ligand binding, a two-step proteolytic cleavage releases the intracellular part of the receptor which translocates to the nucleus and acts as a transcriptional activator. Although Notch-induced transcription of genes has been reported extensively, its endogenous nuclear form ha...

SUMMARY Phylogenetics, likelihood, evolution and complexity (PLEX) is a flexible and fast Bayesian Markov chain Monte Carlo software program for large-scale analysis of nucleotide and amino acid data using complex evolutionary models in a phylogenetic framework. The program gains large speed improvements over standard approaches by implementing 'partial sampling of substitution histories', a da...

Chinese hamster ovary (CHO) cells is one of the most widely used production host for the commercial production of biopharmaceuticals product. They have been extensively studied and developed, and today provide a stable platform for producing monoclonal antibodies and recombinant proteins. This study focused on the production of recombinant protein in suspension culture of CHO cells in spinner f...

s of papers 55 allowed by either oxygen or MAP (not different from each other). Of the treatments evaluated, CO2 allowed the least growth of psychrophiles. Proliferation of E. coli and aerobes was the greatest when packaged in air after 14 d, while CO2 packaging resulted in the least growth. These data suggest that O2 may be a preferred environment, which actually reduced Campylobacter recovery...

In any system with shared data and concurrent (or independent) activities, there is a need to guarantee exclusive access to the shared data. If the independent parts are executed in a non-preemptive fashion, on a single-processor architecture, the exclusive access is automatically guaranteed. The problem arises when the single-processor architecture is to be replaced by a multi-processor ditto;...