320 888-7543/99 $30.00 opyright © 1999 by Academic Press ll rights of reproduction in any form reserved. he Human Gene Nomenclature Committee. The assignment of roups of genes, related by defined levels of sequence similarity, o superfamilies, families, and subfamilies is helpful to nomenlature editors trying to assign gene symbols in a logical, hierrchical, and meaningful system. Once a root (...

Axon-dendrite polarity is likely instructed by extrinsic cues in the developing nervous system, though the mechanisms governing this process remain to be fully elucidated. In this issue of Neuron, Shelly et al. show that the axon guidance cue Semaphorin 3A can promote dendrite growth by inhibiting axon specification.

Collapsin response mediator proteins (CRMPs) are intracellular proteins that mediate signals for several extracellular molecules, such as Semaphorin3A and neurotrophins. The phosphorylation of CRMP1 and CRMP2 by Cdk5 at Ser522 is involved in axonal guidance and spine development. Here, we found that the Ser522-phosphorylated CRMP1 and/or CRMP2 are enriched in the dendrites of cultured cortical ...

Lorentz CU, Alston EN, Belcik T, Lindner JR, Giraud GD, Habecker BA. Heterogeneous ventricular sympathetic innervation, altered -adrenergic receptor expression, and rhythm instability in mice lacking the p75 neurotrophin receptor. Am J Physiol Heart Circ Physiol 298: H1652–H1660, 2010. First published February 26, 2010; doi:10.1152/ajpheart.01128.2009.—Sympathetic nerves stimulate cardiac funct...

dered if guidance cue-induced changes in NFPC protein synthesis may play a role here. Interestingly, stimulating cultured growth cones with Sema3A, a repellent molecule expressed in telencephalic regions adjacent to the MOT, elevates NFPC protein twofold within 10 min. Therefore, we now postulate a growth cone turning mechanism involving Sema3A-induced increases in TAF1mediated NFPC activity at...

Local translation mediates axonal responses to Semaphorin3A (Sema3A) and other guidance cues. However, only a subset of the axonal proteome is locally synthesized, whereas most proteins are trafficked from the soma. The reason why only specific proteins are locally synthesized is unknown. Here we show that local protein synthesis and degradation are linked events in growth cones. We find that g...

dendritic cells: from specific surface markers to specific cellular functions. Hum Immunol. 2002;63(12):1133-1148. 11. Sarris M, Andersen KG, Randow F, Mayr L, Betz AG. Neuropilin-1 expression on regulatory T cells enhances their interactions with dendritic cells during antigen recognition. Immunity. 2008;28(3):402-413. 12. Milpied P, Renand A, Bruneau J, et al. Neuropilin-1 is not a marker of ...