The present investigation was focused to formulate semi-solid capsules (SSCs) of hydrophobic drug telmisartan (TLMS) by encapsulating semi-solid matrix of its solid dispersion (SD) in HPMC capsules. The combinational approach was used to reduce the lag time in drug release and improvise its dissolution. SDs of TLMS was prepared using hot fusion method by varying the combinations of Pluronic-F68...

Abstract Multi-axial compression of the mushy zone occurs in various pressurized casting processes. Here, we present a drained triaxial apparatus for semi-solid alloys that allow liquid to be drawn into or expelled from sample response isotropic compression. The rig is used measure pressure-dependent flow stress and volumetric during isothermal globular Al-15 wt pct Cu at 70 85 vol solid. Analy...

Two important factors affecting hot tearing – semi-solid constitutive behaviour and grain percolation – have been simulated through the use of microstructure models based on granular structures. The semi-solid model geometry is based on a modified Voronoi tessellation, and includes rounded corners to approximate an equiaxed-globular grain structure with liquid surrounding the grains. The percol...

It is well known that semi-solid forming could only obtain coarse-grained microstructure in a few alloy systems with a low melting point, such as aluminum and magnesium alloys. This work presents that semi-solid forming could also produce novel bimodal microstructure composed of nanostructured matrix and micro-sized (CoFe)Ti2 twins in a titanium alloy, Ti62Nb12.2Fe13.6Co6.4Al5.8. The semi-solid...

The growth of colonies in semisolid medium is receiving wide spread attention as a possible test for predicting the clinical response of individual human tumors to specific drugs. One problem encountered in these studies is the difficulty of preparing single-cell suspensions from solid tumors. Often, microscopic examination of the cultures just after plating reveals many clus ters or clumps of ...