Integration of dual-barrel membrane patch-ion channel probes (MP-ICPs) to scanning ion conductance microscopy (SICM) holds promise of providing a revolutionized approach of spatially resolved chemical sensing. A series of experiments are performed to further the understanding of the system and to answer some fundamental questions, in preparation for future developments of this approach. First, ...

Ion-channel sensors can be used for detection of biochemical reagents. A silicon-based ion-channel platform has been developed for stochastic sensing for molecules. In this paper, we present techniques to extract appropriate features from sensor data using a combination Walsh-Hadamard Transform and Principal Component Analysis and use neural network techniques to discriminate between the analytes.