BACKGROUND Studies on time trends of allergic sensitization among adults are rare. The aim of the study was to compare the prevalence of allergic sensitization to common airborne allergens among adults 15 years apart and to identify risk factors for allergic sensitization. METHODS Clinical examinations including skin prick test (SPT) and structured interviews were performed in two random popu...

PURPOSE As pet ownership increases, sensitization to animal allergens due to domestic exposure is a concern. Sensitization to animal allergens may occur from indirect exposure, as well as direct ownership of animals. However, there have been conflicting results regarding the association between pet ownership and sensitization to animal allergens in adults. METHODS In total, 401 patients with ...

BACKGROUND Immune responses in allergic diseases begin with allergen sensitization, which usually occurs in childhood. Allergen sensitization involves a complex interplay of genetic and environmental factors, and sensitization patterns may change with age. OBJECTIVE To determine the predictors of allergen sensitization in the first 3 years of life in the growing up in Singapore towards health...

Gong, Ming Cui, Isabelle Gorenne, Paul Read, Taiping Jia, Robert K. Nakamoto, Avril V. Somlyo, and Andrew P. Somlyo. Regulation by GDI of RhoA/Rho-kinase-induced Ca21 sensitization of smooth muscle myosin II. Am J Physiol Cell Physiol 281: C257–C269, 2001.—We characterized the role of guanine nucleotide dissociation inhibitor (GDI) in RhoA/Rho-kinase-mediated Ca21 sensitization of smooth muscle...

BACKGROUND Atopic patients are exceptionally sensitive to airborne allergens. Sensitization to fungal allergens may be associated with respiratory allergic disease (RAD) and atopic dermatitis (AD). This study investigates the relationship between sensitization to different fungal allergens and the clinical manifestations of atopic disease. METHODS We retrospectively reviewed the medical recor...

Background: The role of total IgE (TIGE) in detecting inhalant allergens (IA) sensitization in asthmatics is controversial and frequently underestimated. Objective: To test the relationship between TIGE and IA sensitization in asthmatics. Methods: One year duration cross-sectional study commencing from January in 2014. 118 asthmatics with mean age of 30±15 years collected from King Abdulaziz Un...

In the present study, we investigated the effects of selective activation or inhibition of ventral tegmental area (VTA) adenylate cyclase (AC) and protein kinase A (PKA) on long-term sensitization induced by repeated intra-VTA or peripheral amphetamine (AMPH). Selective inhibition of AC by SQ 22,536 (9-(tetrahydro-2-furanyl)-9H-purin-6-amine; 100 nmol/side bilateral into VTA) had no effect on a...

BACKGROUND Early-onset atopic dermatitis (AD) is a particular phenotype that may convey a risk of developing multiple sensitizations to allergens but little is known about the pathway of sensitization. The aims of this study were to describe the natural history of sensitization to allergens for this phenotype and to identify the most predictive marker associated with the risk of developing sens...

BACKGROUND Severe asthma is a largely heterogeneous disease with varying phenotypic profiles. The relationship between specific allergen sensitization and asthma severity, particularly in Asia, remains unclear. We aim to study the prevalence of specific allergen sensitization patterns and investigate their association with outcomes in a severe asthma cohort in an Asian setting. METHODS We con...