introduction: tooth pain and sensitization are the two main causes of discomfort after periodontal flap surgery. effects of low level laser therapy for reducing pain have already been established; these kinds of lasers have been used for tooth desensitization as well. this controlled blind study sought to compare tooth pain and sensitization after 660nm laser irradiation in a split mouth and al...

The paper discusses spectral sensitized photo processes in silver bromide caused by dyes adsorbed on the surface of stearate via lightguide mechanism and a direct hit luminescent light from dye molecules localized near microcrystal to bromide. submits an estimation contribution overall sensitization. These calculations demonstrate that particle sensitization stearate—silver structure is compara...

Prostaglandin E(2) (PGE(2)) is a key mediator of exaggerated pain sensation during inflammation. Drugs targeting the PGE(2) pathway by global inhibition of cyclooxygenases are well established in the treatment of inflammatory pain, but also cause significant unwanted effects. Enzymes downstream of the cyclooxygenases, or prostaglandin receptors are candidate targets possibly enabling therapeuti...

erythropoietin (epo) was first known as a factor for red blood cell proliferation and differentiation. recent studies show the effects of epo on immune system. in this study the antihuman leukocyte antibody (anti-hla) titer were determined in five groups of rats, which had been sensitized with human lymphocyte. also, the effects of stimulation's frequency and dose of recombinant human eryt...

This target article examines the clinical and experimental evidence for a role of peripheral and central hyperexcitability in persistent pain in four key areas: cutaneous hyperalgesia, referred pain, neuropathic pain, and postoperative pain. Each suggests that persistent pain depends not only on central sensitization, but also on inputs from damaged peripheral tissue. It is instructive to think...

Sensitization is a common feature of psychostimulants and sensitization effects are generally considered to be linked to the addictive properties of these drugs. We used a conventional paired/unpaired Pavlovian protocol to induce a context specific sensitization to the locomotor stimulant effect of a high dose of apomorphine (2.0mg/kg). Two days following a 5 session sensitization induction pha...

Male flies under the influence of ethanol display disinhibited courtship, which is augmented with repeated ethanol exposures. We have previously shown that dopamine is important for this type of ethanol-induced behavioral sensitization but the underlying mechanism is unknown. Here we report that DopEcR, an insect G-protein coupled receptor that binds to dopamine and steroid hormone ecdysone, is...

Purpose: This article is to evaluate the proportion of mono-sensitization and poly-sensitization based on sIgE composition and to develop a novel diagnostic tool and study the production of different immunoglobulins (Ig) in allergic diseases. Methods: The serum sIgE composition of 2409 patients diagnosed with allergic disease was analyzed using the sIgE immunoblot method. A specific formula was...

A common expression of neuroadaptations induced by repeated exposure to addictive drugs is a persistent sensitized behavioral response to their stimulant properties. Neuroplasticity underlying drug-induced sensitization has been proposed to explain compulsive drug pursuit and consumption characteristic of addiction. The hypothalamic-pituitary-adrenal (HPA) axis-activating neuropeptide, corticot...

Pro-inflammatory prostaglandins are known to enhance the sensitivity of sensory neurons to various modalities of stimulation, including the excitatory chemical agent, capsaicin. In this report, we examined the capacity of prostaglandin E2 (PGE2) to enhance the capsaicin response recorded from sensory neurons isolated from embryonic rats and grown in culture. Previous work demonstrated that the ...