نتایج جستجو برای: seronegative (sn)
تعداد نتایج: 29810 فیلتر نتایج به سال:
high levels of rheumatoid factors (rf) are detectable in serum of the majority of patients with rheumatoid arthritis (ra), but 5-10% of patients remain seronegative (sn). despite clinical and genetic similarities between these two subsets of ra, it has been proposed that they may be regarded as distinct clinical entities. methods: in the present study a panel of monoclonal antibodies (mab) reco...
Rheumatoid Arthritis (RA) is a systemic autoimmune disease. Production of Rheumatoid Factor(RF) is a characteristic feature of the majority RA patients. Previous studies showed there are differences between seropositive-RA(SP-RA) and seronegative-RA(SN-RA), regarding clinical manifestations. In this study the level of CRP was measured in serum and synovial fluid of 45 RA patients by latex a...
High levels of rheumatoid factors (RF) are detectable in serum of the majority of patients with rheumatoid arthritis (RA), but 5-10% of patients remain seronegative (SN). Despite clinical and genetic similarities between these two subsets of RA, it has been proposed that they may be regarded as distinct clinical entities. Methods: In the present study a panel of monoclonal antibodies (mAb) rec...
Antiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial and venous thrombosis, recurrent abortions, and antiphospholipid antibodies (aPL). However, it is possible to find patients with clinical signs of APS who persistently test negative for aPL (seronegative APS, or SN-APS). The aim of this study was to identify new antigenic target(s) of autoantibodies in APS patien...
Myasthenia gravis (MG) is an autoimmune disease mainly caused by antiacetylcholine receptor autoantibodies (seropositive (SP) disease) or by Abs against unknown autoantigenic target(s) (seronegative (SN) disease). Thymectomy is usually beneficial although thymic hyperplasia with ectopic germinal centers is mainly observed in SP MG. To understand the role of thymus in the disease process, we com...
Presence of autoantibodies precedes development of seropositive rheumatoid arthritis (SP RA) and seropositive arthralgia patients (SAP) are at risk of developing RA. The aims of the study are to identify additional serum immune markers discriminating between SP and seronegative (SN) RA, and markers identifying high-risk SAP. Sera from SAP (n = 27), SP RA (n = 22), SN RA (n = 11) and healthy con...
In the clinical practice it is possible to find patients with clinical signs suggestive of antiphospholipid syndrome (APS), who are persistently negative for the laboratory criteria of APS, that is, anti-cardiolipin antibodies (aCL), anti-β2-GPI antibodies and lupus anticoagulant. Therefore, it was proposed for these cases the term of seronegative APS (SN-APS). In order to detect autoantibodies...
The mechanism(s) by which Sin Nombre (SN) hantavirus is maintained in deer mouse populations is unclear. Field studies indicate that transmission occurs primarily if not exclusively via a horizontal mechanism. Using an experimental deer mouse infection model in an outdoor laboratory, we tested whether infected rodents shed SN virus in urine, feces, and saliva, whether infected mice transmit inf...
آرتریت روماتوئید rheumatoid arthritis,(ra) یک بیماری خود ایمن است که یکی از معیارهای تشخیصی آن وجود فاکتور روماتوئید ( rheumatoid factor,rf ) در سرم بیماران می باشد. مطالعات نشان داده اند که بین بیماران آرتریت روماتوئید rf+ و rf- از نظر تظاهرات بافت شناسی ( histologic ) اختلافاتی وجود دارد. در این مطالعه میزان (crp) c-reactive protein و ایزوتیپهای iga rf و igm rf در 45 بیمار مبتلا به ra مورد سن...
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