the core spliceosome? How is RBM15’s association with specific genes regulated? What is the dominant-negative mechanism by which Mpl-TR acts to decrease HSC maintenance? Answers to these questions not only will elucidate critical aspects of the splicing machinery, but will be relevant for our understanding of the role of the RBM15-MKL1 fusion protein in AMKL. Conflict-of-interest disclosure: Th...

the core spliceosome? How is RBM15’s association with specific genes regulated? What is the dominant-negative mechanism by which Mpl-TR acts to decrease HSC maintenance? Answers to these questions not only will elucidate critical aspects of the splicing machinery, but will be relevant for our understanding of the role of the RBM15-MKL1 fusion protein in AMKL. Conflict-of-interest disclosure: Th...

background t-helper (th) lymphocyte cytokine production may be important in the immune pathogenesis of hepatitis c virus (hcv) infections. th1 cytokines such as; interleukin- 2 (il-2), and interferon gamma (ifn-gamma) are necessary for host antiviral immune responses, while th2 cytokines (il-4, il-10) can inhibit the development of these effector mechanisms. objectives the aim of the present st...

background: leishmania is a significant health problem in many parts of the world. tumor necrosis factor (tnf) plays an essential role in leishmania major infections. objective: to study the pro-inflammatory cytokines and antioxidants in four groups of cutaneous leishmaniasis patients. methods: 39 patients were divided into four groups of: 1) active (acute phase of treatment); 2) non-healing (r...

immune and inflammatory responses mediated by cytokines, play important roles in the pathophysiology of asthma. these responses are associated with overexpression of th2 cytokines such as il-4 and il-13. these two cytokines use common receptors for signaling that lead to identical immunological effects and regulation of the th1/th2 balance. the aim of this study was to determine whether patient...