Effect of addition of a permeabilizing agent dimethyl sulfoxide (DMSO) and a solid adsorbent, XAD -7, on growth and coumarin production in hairy root cultures of C. intybus was studied. Continuous permeabilization of the hairy root cultures of C. intybus with DMSO has been shown to be an effective strategy for enhanced release of coumarins while preserving the root viability. DMSO at 0.2% (v/v)...

The seasonal variation of mono-and sesquiterpene emission rates of Scots pine was measured from April to October in 2004. The emission rates were measured daily in the afternoons with the exception of weekends. Emissions were measured from two branches; one of them was debudded in May (branch A), while the other was allowed to grow new needles (branch B). The monoterpene emission pattern remain...

Cinnamon bark is commonly used in traditional Japanese herbal medicines (Kampo medicines). The coumarin contained in cinnamon is known to be hepatotoxic, and a tolerable daily intake (TDI) of 0.1 mg/kg/day, has been quantified and used in Europe to insure safety. Risk assessments for hepatotoxicity by the cinnamon contained in foods have been reported. However, no such assessment of cinnamon ba...

The asymmetric unit of the title compound, {[Na(C(9)H(6)O(3))(H(2)O)(3)](C(9)H(5)O(3))·H(2)O}(n), contains two crystallographically independent Na atoms, two 7-hy-droxy-coumarin ligands, six coordinated water mol-ecules, two 7-hy-droxy-coumarin anions and two uncoordinated water mol-ecules. Both Na atoms exhibit a distorted octa-hedral coordination geometry and are coordinated by five water O a...

Coumarin oral anticoagulant drugs have proven to be effective for the prevention of thromboembolic events. World-wide, warfarin is the most prescribed drug. In Europe, acenocoumarol and phenprocoumon are also administered. Yet it has been proven that variant alleles of the VKORC1 and CYP2C9 genotypes influence the pharmacokinetics and pharmacodynamics of these drugs. The combination of these tw...

Coumarin, the parent compound of warfarin, has been observed to stimulate macrophages, increase phagocytosis, and induce changes in lymphocyte-mitogen responsiveness in cancer patients. Coumarin has been reported to have antitumor activity in human melanomas and renal cancer when used in conjunction with the 11-2antagonist, cimetidine. We have observed that coumarin has antiprostatic activity i...

In the structures of the two title coumarin derivatives, C14H12O6, (1), and C20H16O6, (2), one with acetate and the other with pent-4-ynoate substituents, both the coumarin rings are almost planar. In (1), both acetate substituents are significantly rotated out of the coumarin plane to minimize steric repulsions. One acetate substituent is disordered over two equivalent conformations, with occu...

The genus Moluccella (Lamiaceae) encompasses eight species among which aucheri (Boiss.) Scheen and M. laevis L. are available in Iran. aim of this study is characterizing the essential oil dried aerial parts collected from South was hydrodistilled then analysed by GC-MS. Twenty-one compounds were identified aucheri. most abundant components an aromadendrane sesquiterpene; spathulenol (63.3%) to...

Previous investigations have shown that CY4-labeled transcinnamic acid is rapidly converted to o-coumaric acid P-glucoside by shoots of Melilotus alba (white sweet clover) (1) and Hierochlod odorata (sweet grass) (2). This glucoside is then converted to coumarin (l-3), possibly by way of trans-cis isomerization of the glucoside to coumarinic acid P-glucoside. The small amount of radioactivity f...

PURPOSE To evaluate clinical outcome of cataract surgery under systemic anticoagulant therapy using coumarin. METHODS This clinical interventional comparative nonrandomized study included 441 patients (441 eyes) consecutively undergoing standard phacoemulsification with clear cornea incision and topical anesthesia. The study group consisted of 21 (4.8%) patients for whom systemic coumarin the...