The effects of steroid sex hormones on the established cell lines derived from human urinary bladder cancer, T24, and from human transitional cell cancer of the urinary tract, 253J, were examined using the colony formation method. Of the seven kinds of steroid hormones tested, estradiol-17 beta was intensively cytotoxic for both cells. The cytotoxic effect was depended on the dose and time of t...

In their research article published in the September 9, 2005 issue of Cell, Hammes et al. (2005) investigated the role of megalin (an endocytic receptor in a variety of tissues) and SHBG (sex hormone binding globulin) on the cellular uptake of sex steroid hormones in mice. In plasma, androgens and estrogens can circulate bound tightly to SHBG, bound loosely to albumin, unbound, or free. Althoug...