The L-type Ca2+ channel expressed in gastrointestinal smooth muscle is mechanosensitive. Direct membrane stretch and shear stress result in increased Ca2+ entry into the cell. The mechanism for mechanosensitivity is not known, and mechanosensitivity is not dependent on an intact cytoskeleton. The aim of this study was to determine whether L-type Ca2+ channel mechanosensitivity is dependent on t...

Reinforced concrete beams are normally designed as under-reinforced to provide ductile behaviour at failure i.e. the tensile moment of resistance, Mt(0), is less than the moment of resistance of the compressive zone, Mc. Since it is well established that the steel in reinforced concrete beams is prone to corrosion, the residual flexural strength is normally the main concern of asset managers. H...

Analyzing the vortex-induced vibration of a slender marine structure withlength to diameter ratio up to 200 is the objective of this study. This slender is free to move in both in-line and cross flow directions and immersed completely in water. Three different types of shear currents pass on it and cause to vibrate slender in different forms. Nowadays, these vibrations are very important for de...

Cosmic shear is the distortion of images of distant galaxies due to weak gravitational lensing by the large-scale structure in the Universe. Such images are coherently deformed by the tidal field of matter inhomogeneities along the line of sight. By measuring galaxy shape correlations, we can study the properties and evolution of structure on large scales as well as the geometry of the Universe...

in reinforced concrete design, there are situations where transfer of shear across a specific plane needs to be considered. examples of such situation include corbels, bearing shoes, ledger beam bearing, and a host of connection between precast concrete elements. in this study, the shear transfer behavior of reinforced concrete is investigated experimentally by conducting test on 6 precracked p...

While the occurrence of large amplitude internal waves in the Earth’s natural bodies of water is widely documented, the generation of these waves remains an active area of exploration. We discuss numerical simulations of transcritical flows of a density strat­ ified fluid with a dual focus on the role of a background shear current and transitions of the background current from super to subcriti...

This paper describes the physical mechanisms responsible for turbulence control and transport barrier formation on DIII–D as determined from a synthesis of results from different enhanced confinement regimes, including quantitative and qualitative comparisons to theory. A wide range of DIII–D data support the hypothesis that a single underlying physical mechanism, turbulence suppression via ExB...

Recent study has shown that 3D computations of the morphological development of a coast shows irregularities compared with the 2DH (depth-averaged) computations. Therefore a validation of the surf zone currents computed using the 2DH (depth-averaged) and 3D approach in Delft3D is made. The 2DH and 3D approach are compared using an idealized case and validated using data from the laboratory expe...