Abstract Radix puerariae has become the most commonly used medicine for diabetic nephropathy (DN). However, mechanism of in treatment DN is not completely clear. This study to determine active ingredients, targets, and signaling pathways using network pharmacology analysis animal experiments confirm its possible action. A total 12 potential effective components 10 key therapeutic targets were o...

Primary cilium is a protruding cellular organelle that has various physiological functions, especially in sensory reception. While an avalanche of reports on primary cilia have been published, the function dental cells remains to be investigated. In this study, we focused dentin-producing odontoblasts. Odontoblasts, like most other cell types, possess cilia, which disappear upon knockdown intra...

Bone morphogenetic proteins (BMPs) were originally identified as the active components in bone extracts that can induce ectopic formation. In recent decades, their key role has broadly expanded beyond physiology and pathology. Nowadays, BMP pathway is considered an important player vascular signaling. Indeed, mutations genes encoding different of cause various severe diseases. Their signaling c...

Abstract The Wnt/β-catenin signaling pathway plays crucial roles in embryonic development and the of multiple types cancer, its aberrant activation provides cancer cells with escape mechanisms from immune checkpoint inhibitors. E7386, an orally active selective inhibitor interaction between β-catenin CREB binding protein, which is part pathway, disrupts HEK293 adenomatous polyposis coli (APC)-m...

Dear Editor;
 We read with interest the article titled “CYB mtDNA mutations and expression status of genes in PI3K/AKT/mTOR signaling pathway patients schizophrenia” published Cukurova Medical Journal by Dirican et al.

Objective(s):Inflammatory bowel disease (IBD) results from dysregulation of intestinal mucosal immunity. It is an incurable disease that affects millions of people worldwide. Developing new strategies for the treatment of colitis has been a major challenge. Here, we report the effect of calycosin, a plant-derived flavonoid, in successfully managing colitis in murine model. Material and Methods:...