Diabetes mellitus is a metabolic disorder that results in hyperglycemia due to decreased insulin production or inefficient insulin utilization. This disease has been reported in animals, particularly in aged dogs. However, the disorder is much more prevalent in humans. Millions of people across the globe currently have diabetes and incidence rates are predicted to increase dramatically as the p...

Silymarin, a flavonolignan derived from Silybum marianum, possesses diverse pharmacological activities, including hepatoprotective, antioxidant, anti-inflammatory, anticancer, and cardioprotective. Although clinical trials have shown silymarin is safe at high doses (>1500 mg/day) in humans, the pharmacokinetic studies over the past three decades related to absorption, distribution, metabolism, ...

Treating male albino rats with the pyrethroid insecticide, deltamethrin induced various histological changes in the liver. These changes included congestion of blood vessels, leucocytic infiltration, cytoplasmic vacuolization of the hepatocytes and fatty infiltration. Deltamethrin also caused significant elevation in serum ALT and AST enzymes after 2 and 3 weeks of treatment. . Silymarin, an ex...

Medicinal herbs are significant source of pharmaceutical drugs. Latest trends have shown increasing demand of phytodrugs and some medicinal herbs have proven hepatotprotective potential. Silymarin, a flavonol lignan mixture) extracted from the Silybum marianum (milk thistle) is a popular remedy for hepatic diseases. Today every herbal company is marketing formulations for liver disorders but th...

In Germany since 1980, more than 300 clinical studies have been carried out with standardized phytopharmaceuticals, including Crataegus, Silybum, Ginkgo, Hypericum, Sabal, Urtica, Kava-Kava, Allium sativum, Valeriana, Aesculus, Echinacea, and Viscum drugs. These studies assessed the efficacy of phytopharmaceuticals for the treatment of moderate or moderately severe diseases and prevention. Seve...