A burn is an injury caused by transfer of thermal energy into tissue resulting in disruption of its normal anatomical structure. An experiment was carried out to compare the effect of silymarin and silver sulfadiazine on burned wound healing in rat. In this study, 36 Wistar rats were divided into 6 groups. A burn was generated on the backs of all rats by brass probe. The burned areas in the fir...

Retinal ischaemia is known as the main reason of blindness in disease such as closed angle glaucoma and diabetes. The aim of this study was to investigate the protective effect of silymarin in injuries induced by ischaemic-reperfusion of rabbit eyes. Thirty male adult New Zealand white rabbits were divided into three groups of ten animals each. All animals in the two experimental groups underwe...

The purpose of this study was to develop porous silica nanoparticles (PSNs) as a carrier to improve oral bioavailability of poorly water-soluble drugs, using silymarin as a model. PSNs were synthesized by reverse microemulsion and ultrasonic corrosion methods. A 3-day release formulation consisting of a silymarin solid dispersion, a hydrophilic gel matrix and silymarin-loaded PSNs was prepared....

AIM Recently, we have demonstrated that silymarin has a comparable pharmaceutical activity as Phyllanthus urinaria extract when used to rescue mice from acetaminophen-induced acute liver injury. In the present study, we further compared the therapeutic action of silymarin with N-acetyl cysteine (commonly used in clinical practice for emergency treatments) as a rescuer in mice after administerin...

Silymarin is the most commonly used herbal medicine by patients with chronic liver disease. Silymarin flavonolignans undergo rapid first-pass metabolism primarily by glucuronidation. The aims of this investigation were: (1) to determine the association of UGT1A1*28 polymorphism with the area under the plasma concentration-time curves (AUCs) for silybin A (SA) and silybin B (SB); (2) to evaluate...

AIM Silymarin from Silybum marianum was found to reduce liver injury. The aim of the present study was to investigate the effects of silymarin on hepatic regeneration in partially hepatectomized rats. METHODS Thirty Wistar-Albino rats were divided into 3 groups of 10 animals as sham, control and experimental groups. In the sham group (n=10) abdominal incision was closed after laparotomy. In t...

BACKGROUND Nonmelanoma skin cancer is the most common cancer among humans; solar UV is its major cause. Therefore, it is important to identify agents that can offer protection against this cancer. PURPOSE We evaluated the protective effects of silymarin, a flavonoid compound isolated from the milk thistle plant, against UVB radiation-induced nonmelanoma skin cancer in mice and delineated the ...

Staphylococcus aureus is an opportunistic pathogen and remains a common cause of burn wound infections. Different studies have shown that entrapment of plant-derived compounds into liposomes could increase their anti-Staphylococcus aureus activity. Silymarin is the bioactive extract from the known plant Silybum marianum L. The objective of this study was to evaluate efficacy of silymarin in fre...

Seeds of Silybum marianum which have been used to treat liver diseases have an active component called silymarin. Hairy root cultures of S. marianum could be able to produce silymarin. There is evidence that the use of elicitors has been an important strategy for improving the production of secondary metabolites. Elicitation is an interesting topic to investigate cell signaling pathway in secon...

The effects of Silymarin on growth performance, internal organs, and some blood parameters were investigated in Japanese quail that were subjected to oxidative stress induced by carbon tetrachloride (CCl4). An experiment was conducted as a completely randomized design in a factorial arrangement (2 × 2) with four replicates of 30 birds each. Factors included two levels of Silymarin (0 and 1 mL/k...