The milk thistle of commerce is a standardized preparation extracted from fruits of Silybum marianum, a plant native to the Mediterranean. Silybum marianum extraction has been shown to be amazingly effective at protecting and repairing liver cells. We studied quality of Silymarin distribution in Silybum marianum fruits and methods of increasing out put of extracting. We formulated the extract a...

The milk thistle of commerce is a standardized preparation extracted from fruits of Silybum marianum, a plant native to the Mediterranean. Silybum marianum extraction has been shown to be amazingly effective at protecting and repairing liver cells. We studied quality of Silymarin distribution in Silybum marianum fruits and methods of increasing out put of extracting. We formulated the extract a...

To investigate the effects of silymarin on follicular development, we enrolled 40 healthy women undergoingin vitro fertilization (IVF) due to male factor infertility in this trial. They underwent ovulation induction and on a random and blind basis, patients were assigned to receive silymarin (70 mg x 3/day) or placebo from the beginning of the induction cycle. The number and quality of oocytes ...

The flavonoid silymarin and one its structural components, silibinin, have been well characterized as hepato-protective substances. However, little is known about the biochemical mechanisms of action of these substances. This review deals with recent investigations to elucidate the molecular action of the flavonoid. Three levels of action have been proposed for silymarin in experimental animals...

Treating male albino rats with the pyrethroid insecticide, deltamethrin induced various histological changes in the liver. These changes included congestion of blood vessels, leucocytic infiltration, cytoplasmic vacuolization of the hepatocytes and fatty infiltration. Deltamethrin also caused significant elevation in serum ALT and AST enzymes after 2 and 3 weeks of treatment. . Silymarin, an ex...

Type 2 diabetes mellitus (T2DM) is associated with increased risk of cardiovascular disease and nephropathy-now the leading cause of end-stage renal disease and dialysis in Europe and the United States. Inflammation and oxidative stress play a pivotal role in the development of diabetic complications. Silymarin, an herbal drug with antioxidant and anti-inflammatory properties, may improve glyce...

Aflatoxin B(1) (AFB(1)) is a potent hepatotoxic and hepatocarcinogenic mycotoxin. The mechanism of cellular damage caused by AFB(1) has not been fully elucidated. Lipid peroxidation is one of the main manifestations of oxidative damage and has been found to play an important role in the toxicity and carcinogenesis of many carcinogens. The present investigation aims at assessing the comparative ...

The active ingredient, or liver-protecting compound in milk thistle is known as silymarin. This substance, which actually consists of a group of compounds called flavonolignands, helps repair liver cells damaged by alcohol and other toxic substances by stimulating protein synthesis. By changing the outside layer of liver cells, it also prevents certain toxins from getting inside. Silymarin also...

Silymarin is a hepatoprotective mixture of flavonolignans and flavonoids extracted from the seeds of milk thistle (Silybum marianum L. Gaertn). This study investigates the effect of major bioactive constituents from silymarin, silybin A, silybin B, isosilybin A, isosilybin B, silydianin, silychristin, isosilychristin, and taxifolin, on the expression of ABCA1, an important cholesterol efflux tr...

Silymarin recognized for numerous activities, but the use is limited due to poor aqueous solubility, inefficient intestinal permeability, and low-erratic bioavailability. The aim of current research was formulation spray-dried nanoemulsion enhance solubility silymarin. prepared by titration method, spray died characterized thermal analysis diffraction scanning calorimetry, crystallography x-ray...