The modifying effect of dietary administration of a polyphenolic antioxidant flavonoid silymarin isolated milk thistle [Silybum marianum (L.) Gaertneri] on 4-nitroquinoline 1-oxide (4-NQO)-induced tongue tumorigenesis was investigated in male F344 rats. Based on the results in pilot studies showing that silymarin treatment together with 4-NQO significantly reduced the occurrence of tongue dyspl...

Article history: Received on: 26/07/2015 Revised on: 15/08/2015 Accepted on: 09/09/2015 Available online: 27/09/2015 Objective To evaluate the effect of Polyethylene glycol and β-cyclodextrin on the solubility and dissolution of silymarin, a poorly water soluble herbal drug. Methodology Effects of beta cyclodextrins and Polyethylene glycol on solubility of silymarin were evaluated by phase solu...

The study was designed to evaluate the effect of silymarin alone on hyperlipidaemia within short interval (2 weeks) period on the lipid profile. 20 patients with hyperlipidaemia of various etiologies are involved in this study (13 males, 7 females) randomized into two groups, 10 patients received placebo and 10 patients received silymarin 600mg oral capsule once daily. The lipid profile was mea...

Milk thistle dietary supplements that contain silymarin are widely marketed and used in the USA and other countries for liver enhancement and recovery. More recently, silymarin has also been identified as a possible antiviral for the treatment of hepatitis C virus (HCV) infection. To assess different brands of commercially sold silymarin, 45 products were collected from local stores and analyze...

Silymarin (standardized extract from the seeds of the Silybum marianum) has been used in the supportive therapy of liver diseases and its cytoprotective activity is believed to be based on antioxidant properties. Our previous works showed hypolipidemic effects of silymarin. The ATP-binding cassette (ABC) transporters G5 and G8 play a major role in biliary cholesterol secretion. The ABCA1 transp...

There are currently limited therapeutic regimens available for effective treatment of hepatocellular carcinoma (HCC). Silymarin is a naturally derived polyphenolic antioxidant with hepatoprotective properties and is very widely used in clinical application; however, effect of silymarin on spontaneous HCC has not been studied. Silymarin was evaluated for its efficacy against spontaneous carcinog...

Background: Silymarin, a flavonoid with antioxidant activities and extracted from milk thistle (Silybum marianum), previously used for its liver protection activity has been recently tested for dermatologic disorders Objectives: Our purpose was to summerize all the dermatologic oriented in vitro and in vivo experiments and clinical trials on silymarin. Methods: A systematic review of the litera...

We studied combinatorial interactions of two phytochemicals, curcumin and silymarin, in their action against cancer cell proliferation. Curcumin is the major component of the spice turmeric. Silymarin is a bioactive component of milk thistle used as a protective supplement against liver disease. We studied antiproliferative effects of curcumin alone, silymarin alone and combinations of curcumin...

Radiotherapy is the most common cancer treatment modality applying ionizing radiation. In majority of the cases, RT necessarily affects on normal tissues around the tumor. Silymarin is one of the most important chemical ingredients of the milk thistle. Silymarin composed of six flavonolignans that Silibinin, with 40-50%, is the most one. In view of the innumerable beneficial effects of silymari...

Silymarin is an active constituent contained in the seeds of the milk thistle plant and is widely used as a hepatic protection agent due to its antioxidant-like activity. In the present study we evaluated the potential action of silymarin against cervical cancer and investigated its mechanism of action. Treatment of cervical cancer cells (C-33A) with silymarin resulted in a significant decrease...