BACKGROUND The potential benefit of silymarin (special extract from the fruits of Silybum marianum) in the treatment of liver diseases remains a controversial issue. METHODS For this systematic review electronic databases identified 65 papers for the search terms silymarin, silibinin, silicristin or milk thistle and clinical trial. Only 19 complied with the criteria'double-' or 'single-blind'...

Partial hepatectomy (PHx) is a liver regeneration physiological response induced to maintain homeostasis. Liver regeneration evolved presumably to protect wild animals from catastrophic liver loss caused by toxins or tissue injury. Silymarin (Sm) ability to stimulate liver regeneration has been an object of curiosity for many years. Silymarin has been investigated for use as an antioxidant and ...

OBJECTIVES Based on the previous reports, silymarin can suppress nitric oxide, prostaglandin E2 (PGE2), leukotrienes, cytokines production, and neutrophils infiltration. Regarding the fact that inflammation plays an important role in neuropathic and formalin-induced pain, it was assumed that silymarin could reduce pain. The present study investigates the analgesic effects of silymarin in chemic...

background: sodium arsenite can impair male reproductive function by inducing oxidative stress. silymarin is known as a potent antioxidant.objective: this study was performed to investigate if silymarin can prevent the adverse effect of sodium arsenite on ram sperm viability, motility and mitochondrial membrane potential.materials and methods: epidydimal spermatozoa obtained from ram were divid...

The standardized extract contains flavonolignans, collectively referred to as silymarin. Sometimes the extract itself is called “silymarin”, which can lead to confusion over dosage since the level of flavonolignans (silymarin) in the extract is typically 60 to 80%, depending on the test methodology used. The main flavonolignans found in the extract are silybin (silibin), silychristin, silydiani...

DEAR EDITOR, The recently published an article by Nematbakhsh et al., entitled “Protective role of silymarin and deferoxamine against iron dextran‐induced renal iron deposition in male rats,” had some interesting point’s needs to explain more. They studied rats, which were allocated to six group and they received iron dextran for a period of 4 weeks every other day, but at the beginning of week...

Gossypol, a pigment of cotton, is a hepatic toxin for chickens. Thus, despite its high protein content, inclusion of cottonseed meal in poultry diets is problematic. Silymarin, an extract from milk thistle, has hepatoprotective qualities and could potentially serve as a feed additive to offset the toxicity of gossypol. The objective of this study was to determine if silymarin could counteract g...

OBJECTIVE To determine the radioprotective effects of Silymarin in adult male Sprague-Dawley rats irradiated with γ-rays. METHODS The present experimental study was performed in Tehran University of Medical Sciences, Tehran, Iran from December 2009 to March 2010. The study was performed on 40 rats, which were randomly and equally divided into four groups: 1) control group: neither received Si...

Paracetamol (APAP-Acetaminophen) has been used extensively as antipyretic drug. The purpose of this study was to evaluate the ameliorative role of silymarin or/and Nigella sativa extract against APAP-induced hyperlipidemia in male mice at the biochemical, levels. The mice were divided into seven groups (10/group). The first group was served as control. While, the second group was treated with d...

Cigarette smoke (CS) is a major risk of chronic obstructive pulmonary disease (COPD), contributing to airway inflammation. Our previous study revealed that silymarin had an anti-inflammatory effect in CS-exposed mice. In this study, we attempt to further elucidate the molecular mechanisms of silymarin in CS extract (CSE)-induced inflammation using human bronchial epithelial cells. Silymarin sig...