Drosophila tracheal terminal branches are plastic and have the capacity to sprout-out projections towards oxygen-starved areas, in a process analogous to mammalian angiogenesis. It was previously shown that this sprouting response involves the upregulation of the FGF homolog Branchless in hypoxic tissues, which binds its receptor Breathless on tracheal cells, thereby attracting the outgrowth of...

G. SOCOL, M. SOCOL, L. SIMA, S. PETRESCU, M. ENCULESCU, F. SIMA, M. MIROIU, G. POPESCU-PELIN, N. STEFAN, R. CRISTESCU, C.N. MIHAILESCU, A. STANCULESCU, C. SUTAN, I.N. MIHAILESCU National Institute for Lasers, Plasma and Radiation Physics, Magurele, Ilfov, Romania National Institute of Materials Physics, Magurele, Ilfov, Romania Institute of Biochemistry, Splaiul Independentei 296, Bucharest, Ro...

Fluorescence imaging is a powerful method for monitoring dynamic signals in the nervous system. However, analysis of dynamic fluorescence imaging data remains burdensome, in part due to the shortage of available software tools. To address this need, we have developed SIMA, an open source Python package that facilitates common analysis tasks related to fluorescence imaging. Functionality of this...

In this article a topographical description of the Cueva Mayor Cueva de Silo cave system is provided, including a more detailed topography of the Sala de los Ciclopes Sala de las Oseras-Sima de los Huesos sector. The history of the excavations and discoveries of human and carnivore fossils in Sima de los Huesos and adjacent passages is briefly reported, as well as the increase, throughout the s...

Abstract Mathematics education research has been aware that calculus students can draw on single definite integrals as a model to compute areas (SImA), without minding whether the function changes its sign in assigned interval. In this study, I take conceptual and empirical steps understand phenomenon more depth. Building Fischbein’s theory, conceptualize area figural concept associate calculat...

BACKGROUND Although previous studies have demonstrated that patients receiving bilateral internal mammary artery (BIMA) conduits during coronary artery bypass grafting have better long-term survival than those receiving a single internal mammary artery (SIMA), data on risk of repeat revascularization are more limited. In this analysis, we compare the timing, frequency, and type of repeat corona...

In a recent paper Sima, Van Huffel and Golub [Regularized total least squares based on quadratic eigenvalue problem solvers. BIT Numerical Mathematics 44, 793 812 (2004)] suggested a computational approach for solving regularized total least squares problems via a sequence of quadratic eigenvalue problems. Taking advantage of a variational characterization of real eigenvalues of nonlinear eigen...