Slack (Slo2.2) is a sodium-activated potassium channel that regulates neuronal firing activities and patterns. Previous studies identified Slack in sensory neurons, but its contribution to acute and chronic pain in vivo remains elusive. Here we generated global and sensory neuron-specific Slack mutant mice and analyzed their behavior in various animal models of pain. Global ablation of Slack le...

A mixture experiment is one where the response depends only on the relative proportions of the ingredients present in the mixture. There are different regression models used to analyze mixture experiments, such as Scheffé model, slack-variable model, and Kronecker model. Interestingly, slack-variable model is the most popular one among practitioners, especially formulators. In this paper, I wan...

Bus schedules cannot be easily maintained on busy lines with short headways: Experience shows that buses offering this type of service usually arrive irregularly at their stops, often in bunches. Although transit agencies build slack into their schedules to alleviate this problem − if necessary holding buses at control points to stay on schedule − their attempts often fail because practical amo...

Measuring and improving the efficiency of organizations, as one of the most important parts of the organization's performance evaluation and a tool to control it, is a contemplative issue in order to survive and advance in the area of competition. Transportation is also a key element in the growth and development of countries that creates an unbreakable link among the various sections of the ec...

Many economists expect inflation to rise in 1995. These expectations are based on various approaches to forecasting inflation. One approach is based on the standard economic theory that inflation rises when slack is eliminated from the economy and production exceeds capacity constraints. According to this view, measures of economic slack such as unemployment and capacity utilization provide use...

S lack can act as a double-edged sword. While it can buffer against environmental threats to help ensure business continuity, slack can also be costly and reduce profitability. In this study we focus on operational slack, the form related to the firm’s production processes. We investigate the role of operational slack on firm survival during its venture stage when its survival is significantly ...

In this short note, we derive dissipative conditions with slack variables for a linear coupled differentialdifference (CDDS) via constructing a Krasovskii functional. The approach can be interpreted as a generalization of the Finsler Lemma approach for standard LTI systems proposed previously in de Oliveira & Skelton (2001). We also show that the proposed slack variables scheme is equivalent to...

Kcnt1 encoded sodium-activated potassium channels (Slack channels) are highly expressed throughout the brain where they modulate the firing patterns and general excitability of many types of neurons. Increasing evidence suggests that Slack channels may be important for higher brain functions such as cognition and normal intellectual development. In particular, recent findings have shown that hu...

Abstract The sodium-activated potassium channel Slack (Kcnt1, Slo2.2) is highly expressed in dorsal root ganglion neurons where it regulates neuronal firing. Several studies have implicated the Slack channel in pain processing, but the precise mechanism or the levels within the sensory pathway where channels are involved remain unclear. Here, we furthered the behavioral characterization of Slac...

Many classification problems involve loss functions different from the usual zero-one classification loss. In recent years, several approaches to accommodate loss functions in kernel-based learning algorithms have been suggested, but the construction of kernels has not been motivated by specific loss functions. We propose a method for deriving kernels from probabilistic models, which is tailore...