The present study was performed to investigate the involvement of SNARK in physical activity levels in mice. To examine the acute effect of SNARK deficiency on voluntary running, Snark-deficient mice (Snark(+/-): n = 16) and their wild-type counterparts (Snark(+/+): n = 16) were assigned to sedentary or exercise (1 wk voluntary wheel running) groups. In addition, to clarify the differences in v...

Subtraction hybridization after the exposure of keratinocytes to ultraviolet radiation identified a differentially expressed cDNA that encodes a protein of 630 amino acid residues possessing significant similarity to the catalytic domain of the sucrose-non-fermenting protein kinase (SNF1)/AMP-activated protein kinase (AMPK) family of serine/threonine protein kinases. Northern blotting and rever...

If your Snark be a Snark, that is right: Fetch it home by all means-you may serve it with greens, And it's handy for striking a light. "But oh, beamish nephew, beware of the day, If your Snark be a Boojum! For then You will softly and suddenly vanish away, And never be met with again!" Lewis Carroll The Hunting of the Snark

In his Master’s thesis, Ján Mazák proved that the circular chromatic index of the type 1 generalized Blanuša snark B n equals 3+ 2 n . This result provided the first infinite set of values of the circular chromatic index of snarks. In this paper we show the type 2 generalized Blanuša snark B n has circular chromatic index 3 + 1 b1+3n/2c . In particular, this proves that all numbers 3 + 1/n with...

We recently described that the anti-apoptotic AMPK-related kinase, SNARK, promotes transforming growth factor (TGF)-β signaling in hepatocellular carcinoma (HCC) cells, as a potentially new therapeutic target. Here we explored FDA-approved drugs inhibiting the enzymatic activity of SNARK, using an in vitro luminescence kinase assay system. Interestingly, the long-used anti-alcoholism drug disul...

Mohar and Vodopivec [Combinatorics, Probability and Computing (2006) 15, 877-893] proved that for every integer k (k > 1 and k 6= 2), there exists a snark which polyhedrally embeds in Nk and presented the problem: Is there a snark that has a polyhedral embedding in the Klein bottle? In the paper, we give a positive solution of the problem and strengthen Mohar and Vodopivec’s result. We prove th...

The signaling mechanisms that mediate the important effects of contraction to increase glucose transport in skeletal muscle are not well understood, but are known to occur through an insulin-independent mechanism. Muscle-specific knockout of LKB1, an upstream kinase for AMPK and AMPK-related protein kinases, significantly inhibited contraction-stimulated glucose transport. This finding, in conj...

A snark is a bridgeless cubic graph which is not 3-edge-colourable. The oddness of a bridgeless cubic graph is the minimum number of odd components in any 2factor of the graph. Lukot’ka, Mácajová, Mazák and Škoviera showed in [Electron. J. Combin. 22 (2015)] that the smallest snark with oddness 4 has 28 vertices and remarked and that there are exactly two such graphs of that order. However, thi...

Tangibles, in the form of physical artefacts that are electronically augmented and enhanced to trigger various digital events to happen, have the potential for providing innovative ways for children to play and learn, through novel forms of interacting and discovering. They offer, in addition, the scope for bringing playfulness back into learning. To this end, we designed an adventure game, whe...