background: coronary artery disease (cad) is a multifactorial and heterogenic disease. recently, genome-wide association studies have reported that rs1333040 (c/t) and rs1004638 (a/t) single nucleotide polymorphisms (snps) in the 9p21 locus have very strong association with cad. this study aimed to examine these associations in southwest of iran. methods: blood samples were collected from 200 c...

Single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 4 (TLR4) gene have been documented type 2 diabetes mellitus (T2DM) and other diseases Saudi population. We investigated relationship between rs11536889, rs4986790, rs4986791 SNPs TLR4 T2DM population; 105 patients with healthy controls were analyzed. The was amplified through PCR, followed by restriction fragment length polymorphi...

Single nucleotide polymorphisms (SNPs) are a hot item in current discussions about the practical applications of genomics and Human Genome Project research. SNPs are simply DNA point mutations—single base-pair changes or insertion/deletions—that are present at measurable frequencies in the population. SNPs are the most common variations in the human genome; the current estimate is that SNPs occ...

Single nucleotide polymorphisms (SNPs) are an abundant form of genome variation, distinguished from rare variations by a requirement for the least abundant allele to have a frequency of 1% or more. A wide range of genetics disciplines stand to benefit greatly from the study and use of SNPs. The recent surge of interest in SNPs stems from, and continues to depend upon, the merging and coincident...

Staphylococcus aureus stifles its host's immune response by producing an immunosuppressive molecule, report Thammavongsa and colleagues. The new study reveals that without the cell wall enzyme adenosine synthase A (AdsA), most staphylococci fail to thrive and cause severe disease in mice. The gene encoding AdsA contains a 5 Ј-nucleotidase domain, making it similar to a family of mammalian enzym...

Genome-scale networks can now be reconstructed based on high-throughput data sets. Mathematical analyses of these networks are used to compute their candidate functional or phenotypic states. Analysis of functional states of networks shows that the activity of biochemical reactions can be highly correlated in physiological states, forming so-called co-sets representing functional modules of the...

Sodium hydroxide (NaOH) has been shown to result in fast nucleation of highly monodispersed silica nanoparticles (SNPs). However, limited work reported on the physicochemical properties resulting SNPs and their surface modification. Herein, we demonstrate that NaOH results poor hydrolysis precursor, with adsorbed sodium ions thermally unstable siloxane cross-linkage. The are removed by refluxin...

the gene coding claudin (cldn5) is located on 22q11. since the proteins of cldn5 family are a ma-jor component for barrier-forming tight junctions, it may be important to test whether or not the cldn5 locus could be associated with schizophrenia.a total of 150 individuals affected with schizophrenia and 150 healthy persons were recruited. the relation-ship between the three single nucleotide po...