solid dispersions in water-soluble carriers have attracted considerable interest as a means of improving the dissolution rate, and hence possibly bioavailability, of a range of hydrophobic drugs. the poor solubility of carvedilol leads to poor dissolution and hence variation in bioavailability. the purpose of the present investigation was to increase the solubility and dissolution rate of carve...

A trend of significant increase in municipal solid waste generation has been recorded worldwide. This has been found due to over population growth rate, industrialization, urbanization and economic growth. Consumerism speed has been found very high covering around more then 50% of total population since last decade due to higher economic growth, which has ultimately resulted in increased solid ...

An outdoor pilot-scale study was undertaken to pretreat municipal solid waste by windrow composting. The raw waste was introduced to active composting without any source separation or pulverization. Pretreatment indicators were developed and used as a tool to measure the optimum level of sorting and waste stabilization. The moisture content of the waste dropped from 68% to 61% and the pile atta...

objective(s):solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. the aim of this study was to compare the effect of polyvinylpyrrolidone k30 (pvp) and poloxamer-188 (plx) as carrier in solid dispersion formulations of celecoxib (clx). materials and methods: solid dispersions of clx:pvp or clx:plx were prepared at different r...