本研究では，薬物非晶質ナノ粒子形成型固体分散体製剤（Amorphous solid dispersion: ASD）の開発および薬物非晶質ナノ粒子形成が薬物吸収性に及ぼす影響の定量的評価を行った．難水溶性モデル薬物としてfenofibrate（FFB），ポリマー担体としてhypromellose（HPMC）を用い，噴霧乾燥によりFFB/HPMC ASDを調製した．FFB/HPMC物理的混合物（Physical mixture: PM）懸濁液中では，μmオーダーのFFB結晶が分散していた一方，FFB/HPMC ASD懸濁液では非晶性の約160 nmのナノ粒子の形成が認められた．FFB/HPMC ASD懸濁液中に溶解したFFB濃度は，FFB/HPMC PM懸濁液と比較して約8.6倍高い値を示した．ラット小腸上皮細胞へのナノ粒子の取り込みを評価した結果，ナノサイズの非晶質FFB粒子が直接小...

The purpose of the present study was to investigate the effect of polyethylene glycol (PEG) molecular weights (6000, 12000 and 20000) as solid dispersion (SD) carriers on the dissolution behavior of simvastatin. SDs with various drug : carrier ratios were prepared by solvent method and evaluated for dissolution rate. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), infrared spe...

In order to increase the dissolution rate and bioavailability, solid dispersions of evodiamine in PVP K(30) with different enriched samples of evodiamine to PVP K(30) ratios were prepared by solvent method. Our studies showed that the dissolution rate of evodiamine was significantly higher in the solid dispersion system in comparison with that in enriched samples of evodiamine or physical mixtu...

PURPOSE The purpose of this study was to prepare and characterize solid dispersion formulation of furosemide to enhance dissolution rate. METHODS Solid dispersions with different drug: carrier ratios were prepared by cogrinding method using crospovidone and microcrystalline cellulose as carrier. The physical state and interactions between the drug and carrier were characterized by Fourier tra...