The first solid phase extraction materials for selective lysophosphatidic acid (LPA) enrichment from human plasma are described. Molecularly imprinted polymers were designed, synthesized and evaluated as cartridge fillings. They enabled a relatively rapid and simple extraction protocol for LPA without any need for multiple liquid-liquid extraction steps. The five major subspecies of lysophospha...

The determination of propoxyphene in oral fluid using solid-phase extraction and gas chromatography-mass spectrometry is described for the first time. The method employs collection of oral fluid with the Quantisal device, immunoassay screening of the specimen, confirmation of the positive screened samples after extraction using cation exchange/hydrophobic solid-phase extraction columns, optimiz...

Bendamustine (BD), a volatile anti-cancer drug in Japan, was quantitatively evaluated using solid phase extraction (SPE)-type device designed for the adsorption of gaseous semi-volatile organic compounds. First, stability BD tested various conditions, including solvent, temperature, and contact with oxygen. Then, standard solution spiked on filter paper, SPE-type connected to downstream. The we...

An exhaustive classification of matrix effects occurring when a sample preparation is performed prior to liquid-chromatography coupled to mass spectrometry (LC-MS) analyses was proposed. A total of eight different situations were identified allowing the recognition of the matrix effect typology via the calculation of four recovery values. A set of 198 compounds was used to evaluate matrix effec...

A solid phase extraction method for removing polar tritiated contaminants from tritium-containing waste oils has been developed. The composition of the degradation products present in the waste oil was determined. The results indicated that upon exposure to tritium gas, fragment methyl ketones, carboxylic acids, and lactones were the main polar products of the mineral-based oil oxidation. The n...

Aims: The aim of the study was to analyse ETG in hair samples treated by a hair straightener. Methods: Positive EtG hair samples were treated with hair straightener during 1 min at 200°C. Treated and non treated hair were analysed for EtG by GC/MS-NICI after solid phase extraction and heptafluorobutyric anhydride derivatization . Results: In 11 samples an average decrease was found 24% and in 5...