Pharmaceutical availability of diazepam, oxazepam and nitrazepam from solid dispersions of PEG 6000 have been studied in comparison with corresponding physical mixtures and pure benzodiazepines. Selected derivatives of 1,4-benzodiazepin-2-one are poorly water soluble drugs. The aim of this work was to report the properties of diazepamand nitrazepam-PEG 6000 solid dispersions. Differential scann...

The arithmetic of the equation a1x d 1 + a2x d 2 + a3x d 3 = 0 is considered for d > 2, with the outcome that the set of coefficients for which the equation admits a non-zero integer solution is shown to have density zero.

In this study, the ion association phenomenon in the saturated solution of KCl in the mixed solvent(methanol+water) was studied. The solubility of this compound in the mixed solvent (methanol+water by value percent of methanol = 60%), and in the presence of various molarities of NaNO3 wasdetermined by the solvent evaporation method at 25.0°C. The results enable us to estimate the valueof thermo...

The Hildebrand solubility parameters have been calculated for eight ionic liquids. Retention data from the inverse gas chromatography measurements of the activity coefficients at infinite dilution were used for the calculation. From the solubility parameters, the enthalpies of vaporization of ionic liquids were estimated. Results are compared with solubility parameters estimated by different me...

Ftibamzone (FBZ) is known to be effective against herpes simplex virus that causes genital herpes but poor solubility of FBZ has reduced its therapeutic efficacy. We investigated water-soluble complexes of various nanoparticles with FBZ to improve its solubility as well as increase its absorption. Using phase-solubility technique, we measured formation constant (K1:1 and K1:2) values at room te...

Here we show the retrograde solubility of various hybrid perovskites through the correct choice of solvent(s) and report their solubility curves. Retrograde solubility enables to develop inverse temperature crystallization of FAPbX3 (FA = HC(NH2)2(+), X = Br(-)/I(-)). FAPbI3 crystals exhibit a 1.4 eV bandgap--considerably narrower than their polycrystalline counterparts.

tant molecular property, playing a large role in the behavior of compounds in many areas of interest. Given the importance of solubility, a means of prediction based solely on molecular structure should prove a useful tool, as many compounds exist for which the solubility simply is not available. The solubility of chemicals and drugs in the water phase has an essential influence on the extent o...

The effects of F, B203 and P205 on the H 2 0 solubility in a haplogranite liquid (36wt .% SiO2, 39 wt. % NaA1Si3Os, 25 wt. % KAISi3Os) have been determined at 0.5, 1, 2, and 3 kb and 800, 850, and 900 ~ The H20 solubility increases with increasing F and B content of the melt. The H 2 0 solubility increase is more important at high pressure (2 and 3 kb) than at low pressure (0.5 kb). At 2 kb and...

Holtz, F., Behrens, H., Dingwell, D.B. and Taylor, R.P., 1992. Water solubility in aluminosilicate melts of haplogranite composition at 2 kbar. In: Y. Bottinga, D.B. Dingwell and P. Richet (Guest-Editors), Silicate Melts. Chem. Geol., 96: 289-302. The compositional dependence of H20 solubility was investigated at 2 kbar and 800 °C in haplogranite melts (system SiO2-NaAISi3Os-KA1Si308 or Qz-Ab-O...