One hypothesis is that the activation of innate immunity and release cytokines breaks down blood brain barrier (BBB) causes neuroinflammation. Here, I present a case COVID-19 associated MIS-C (multisystem inflammatory syndrome in children) with neurological complications manifesting as encephalopathy cytotoxic lesion corpus callosum (CLOCC) on MRI, association extremely elevated levels circulat...

In this cross-sectional study, we analysed serum concentrations of soluble markers of cellular immune activation, namely, interferon-gamma, neopterin (a product of activated macrophages), soluble interleukin-2 receptor, and soluble CD8, in 25 patients with congestive heart failure. Ten (40%) patients showed increased concentrations (i.e. above the reference ranges of healthy controls) of neopte...

In Crohn's disease, the activity of the disease is sometimes difficult to evaluate and the evolution of the disease is difficult to predict. The soluble interleukin-2 receptor serum level has been reported to correlate with clinical activity of the disease and with mucosal immune activation. We compared serum soluble interleukin-2 receptor to classical inflammatory markers and other immune para...

OBJECTIVE To determine whether serum soluble interleukin 2 receptor concentrations are related to disease activity in atopic eczema. DESIGN Single cohort longitudinal study with controls. SETTING Outpatient and general medicine departments in secondary referral centre. PATIENTS Of 15 patients aged 17-57 with severe atopic eczema, all with acute exacerbations of disease, 13 were admitted t...