Planarizable push–pull flipper probes have been introduced to image order and tension of membranes in living cells. In this report, we show that fluorescent flippers can also be planarized by chemical interactions on DNA architectures rather than physical forces biomembranes. Compared fluorescence water, the planarization parallel cMyc G-quartets is characterized a 100 nm red shift excitation m...

This study describes the synthesis, photophysical characterization, and TD-DFT calculation of a series benzothiazole-based styryl fluorophores (F1-F5) harboring D-π-A structure. The compounds were obtained through simple efficient synthetic route using low-cost starting materials. investigation analysis their properties enable assessment effect four substituted benzothiazole moieties (A) two ty...

Pyrene derivatives show immense potential as sensitizers for dye-sensitized solar cells (DSCs). Therefore, this work focuses on the impact of π-spacers on the photophysical, electrochemical and photovoltaic properties of pyrene based D-π-A dyes, since the insertion of π-spacers is one of the doable strategies to improve the light harvesting properties of the dye. In this respect, three new pyre...

Regioselective nucleophilic addition of bisnucleophiles 1,2-benzenediamine, 2-amino-benzenethiol, and N-phenyl-1,2-benzenediamine to 1,3-diphenylbenzo[e][1,2,4]triazin-7(1H)-one (1) at C6 followed by intramolecular cyclocondensation at the C7 carbonyl afforded highly coloured tetracenes 1,3-diphenyl-1,6-dihydro-[1,2,4]triazino[5,6-b]phenazin-4-ium 4-methylbenzenesulfonate (12), 1,3-diphenyl-1H-...

IR and Raman frequency shifts have been reported for numerous probes of enzyme transition states, leading to diverse interpretations. In the case of the model enzyme ketosteroid isomerase (KSI), we have argued that IR spectral shifts for a carbonyl probe at the active site can provide a connection between the active site electric field and the activation free energy (Fried et al. Science 2014, ...

Three symmetric alkylamino-substituted perylene bisimides with different n-alkyl chain lengths (n = 6, 12, or 18), 1,7-bis-(N,N-dialkylamino)perylene bisimides (1a-1c), were synthesized under mild condition and were characterized by ¹H NMR, ¹³C NMR and high resolution mass spectroscopy. Their optical and electrochemical properties were measured using UV-Vis and emission spectroscopic techniques...

Five new ?-conjugated chromophores derived from acrylic acid and acrylonitrile were synthesized their thermal photophysical behaviors analyzed. They designed through Knoevenagel condensations between arylacetylenebenzaldehydes a methylene group activated cyanoacetic malonic acids. The characterization of the target compounds was performed by Fourier transform infrared spectroscopy (FTIR), 1H nu...

Cyclooxygenase-2 (COX-2) fluorescent probes are promising tools for early diagnosis of cancer. Traditionally, COX-2 were designed by connecting two parts, a fluorophore and binding unit, via flexible linker. Herein, new class COX-2-specific have been developed one-step modification from rofecoxib an integrative approach to combine the unit into one. Among them, several analogues not only exhibi...