Sonodynamic therapy (SDT) kills tumor cells through the synergistic effects of ultrasound (US) and a sonosensitizer agent. 5-Aminolevulinic acid (5-ALA) has been used as a sonodynamic sensitizer for cancer treatment. However, studies have shown that 5-ALA-based SDT has limited efficacy against malignant tumors. In this study, we examined whether artesunate (ART) could enhance the cytotoxicity o...

Suspensions of oxygen-filled bubbles are under active investigation as potential means relieving tissue hypoxia. Intravenous administration large quantities is, however, undesirable. Previous work by the authors has demonstrated that tumor oxygen levels can be increased following oral phospholipid stabilized nanobubbles. The aim this study was to determine whether would enhance efficacy sonodyn...