BACKGROUND Narcolepsy is a neurologic disorder characterized by excessive daytime sleepiness, symptoms of abnormal rapid eye movement (REM) sleep, and a strong association with HLA-DRB1*1501, -DQA1*0102, and -DQB1*0602. Here, we investigated the clinico-physical characteristics of Korean patients with narcolepsy, their HLA types, and the clinical utility of high-resolution PCR with sequence-spe...

This paper pursues a novel analysis of Mandarin rhotacization using Sonority Scale and characterizes this phonological process computationally with BOOLEAN MONADIC RECURSIVE SCHEMES (BMRSs, Chandlee & Jardine 2021). shows an asymmetry between high front vowels (i.e. [i, y] back [u] vowels. Diverging from previous phonetics-based accounts to explain (Chao 1968; Duanmu 2007; a. o.), I propose...

Treiman (1983) and others have argued that spoken syllables are best characterized not as linear strings of phonemes, but as hierarchically organized units consisting of an onset (initial consonant or consonant cluster) and a rime (the vowel and any following consonants) and that the rime is further divided into a peak or nucleus (the vowel) and a coda (the final consonants). It has also been a...

We study a risk-constrained version of the stochastic shortest path (SSP) problem, where the risk measure considered is Conditional Value-at-Risk (CVaR). We propose two algorithms that obtain a locally risk-optimal policy by employing four tools: stochastic approximation, mini batches, policy gradients and importance sampling. Both the algorithms incorporate a CVaR estimation procedure, along t...

AIM P-glycoprotein, the product of the ATP-binding cassette subfamily B member 1 (ABCB1) gene (or the so-called multidrug resistance 1 gene), is an ATP-driven efflux pump contributing to the pharmacokinetics as well as the pharmacokinetics of drugs that are P-glycoprotein substrates, such as tacrolimus. This paper describes the development of a new method for detection of the 3435C/T and 2677G/...

BACKGROUND AND OBJECTIVES Although widely used, serological typing of HLA loci does not always produce uequivocal results. This may be particularly the case for cord blood since samples may be of small volume and poor quality, and contaminated. DESIGN AND METHODS We typed 220 cord blood units (CBU) for HLA class I antigens using the serological technique. For those samples giving doubtful res...