Spermatogenesis, the formation of sperm, is a complex developmental process that begins with the mitotic proliferation of spermatogonia and proceeds through extensive morphological changes that convert the haploid spermatid into a mature, functional spermatozoon. Although the process of spermatogenesis is the same in both mammalian and nonmammalian vertebrates, its control mechanisms are not we...

Abstract Study question Does IGF2BP3 regulate Tcf4 mRNA stability in an N6-methyladenosine (m6A)-dependent manner, affect spermatogenesis, and lead to idiopathic non-obstructive azoospermia (iNOA)? Summary answer induces apoptosis of spermatogenic cells by regulating the m6A-dependent which turn affects spermatogenesis leading iNOA. What is known already Azoospermia most serious phenotype male ...

The effect of 3 months exposure to short day length (L:D, 9:15) on spermatogenesis in R. cyanophlyctis was studied. There was no difference in the qualitative and quantitative aspect of spermatogenesis between control frogs exposed to ambient photoperiod (L:D, 12.16:11.44) and frogs exposed to short day light. The present findings indicate that light has no role in spermatogenesis in the frog.

Human infertility affects 10–15% of couples, half of which is attributed to the male partner. Abnormal spermatogenesis is a major cause of male infertility. Characterizing the genes involved in spermatogenesis is fundamental to understand the mechanisms underlying this biological process and in developing treatments for male infertility. Although many genes have been implicated in spermatogenes...

background: the global prevalence of diabetes mellitus is on rise. diabetes-induced oxidative stress has been known to affect liver, pancreas, kidney and reproductive organs pathologically. honey is a natural product of bee with antioxidant properties. objective: current study aimed to analyze the protective effects of metformin (mf) alone and mf+ natural honey co-administration on diabetes-ind...

Throughout spermatogenesis multiplication, maturation and differentiation of germ cells results in the formation of the male gamete. The understanding of spermatogenesis needs detailed informations about the organization of the germinal epithelium, the structure and function of different types of germ cells, endocrine and paracrine cells and mechanisms, intratesticular and extratesticular regul...

THE EFFECT OF ALOE VERA HYDROALCOHOLIC EXTRACT ON SPERMATOGENESIS PARAMETERS AND HISTOLOGICAL CHANGES IN TESTIS RATS FED WITH A HIGH-FAT DIET

Epigenetic modifications change gene expression in such a way that gene action is affected without change in DNA sequence. Several genes playing crucial roles in spermatogenesis are known to be epigenetically regulated. Epigenetic modifications affect spermatogenesis, and aberrant epigenetic modifications at certain loci are linked to male infertility. Epigenetic modifications could be the mech...

background: different investigation showed that 5-methoxypsoralen and 8- methoxypsoralen reduce birth rates in the rats. objective: in this study we worked out the effect of methoxsalen together with ultraviolent a (uva) radiation on mature balb/c mice spermatogenesis. materials and methods: the ld50 standard was determined 160 mg/kg and the uva dose which causes erythema was calculated 0.046 j...