Human infertility affects 10-15% of couples, half of which is attributed to the male partner. Abnormal spermatogenesis is a major cause of male infertility. Characterizing the genes involved in spermatogenesis is fundamental to understand the mechanisms underlying this biological process and in developing treatments for male infertility. Although many genes have been implicated in spermatogenes...

Spermatogenesis is composed of three distinctive phases, which include self-renewal of spermatogonia via mitosis, spermatocytes undergoing meiosis I/II and post-meiotic development of haploid spermatids via spermiogenesis. Spermatogenesis also involves condensation of chromatin in the spermatid head before transformation of spermatids to spermatozoa. Epigenetic regulation refers to changes of h...

BACKGROUND Spermatogenesis is a complex process involving cell development, differentiation and apoptosis. This process is governed by a series of genes whose expressions are highly regulated. Male infertility can be attributed to multiple genetic defects or alterations that are related to spermatogenesis. The discovery, cloning and further functional study of genes related to spermatogenesis i...

We previously reported the successful induction and completion of mouse spermatogenesis by culturing neonatal testis tissues. The culture medium consisted of α-minimum essential medium (α-MEM), supplemented with Knockout serum replacement (KSR) or AlbuMAX, neither of which were defined chemically. In this study, we formulated a chemically defined medium (CDM) that can induce mouse spermatogenes...

BACKGROUND There are numerous investigations on wide range of issues that disrupt regulatory spermatogenesis, individuals who are exposed to drug abuse faced infertility and immature spermatogenesis. OBJECTIVE The aim of this study was to evaluate the addiction effects of morphine and its derivatives on rats spermatogenesis. MATERIALS AND METHODS 40 male Wistar rats were randomly divided in...

objective(s): reproductive dysfunction is a consequence of diabetes. diabetes is associated with changes in testicular tissue. sesame oil contains large amounts of polyunsaturated fatty acids and lignin with antioxidant activity, vitamin e, and monounsaturated fatty acid (mufa). the present study investigated the effects of sesame on testis histology and male reproductive parameters in streptoz...

metronidazole and its derivatives have both antiprotozoal and anti bacterial effects. the reproductive toxicity of metronidazole has been observed in some studies. the aim of this study was to determine the detrimental effects of metronidazole on spermatogenesis and testicular androgenesis in male adult rats. eighteen male wistar rats (70-90 days old) were randomly divided into three groups. an...

A photographic description of meiosis and spermatogenesis in single sperm cysts of Drosophila melanogaster cultured in vitro is presented. In addition to the utility of this description for the study of spermatogenesis in whole live testes, the culture procedure provides a means for studying the dynamic development of individual sperm cysts from flies carrying male-sterile mutations, as illustr...

Research on in vitro spermatogenesis is important for elucidating the spermatogenic mechanism. We previously developed an organ culture method which can support spermatogenesis from spermatogonial stem cells up to sperm formation using immature mouse testis tissues. In this study, we examined whether it is also applicable to mature testis tissues of adult mice. We used two lines of transgenic m...

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