The purpose of the study was to evaluate the suitability of laboratory scale spheronizer for the production of spherical pellets loaded with diltiazem hydrochloride by wax combination. The 1:1 combination of cetyl alcohol and hydrogenated castor oil, as low and high melting point waxes, were used. The various production variables affecting the different characteristics of pellets and the proces...

BACKGROUND Flow patterns in univentricular hearts may have clinical value. Therefore, it is our objective to asses and characterize vortex flow patterns with Fontan circulation in comparison with healthy controls. METHODS Twenty-three patients (8 Fontan and 15 normal patients) underwent echocardiography with intravenous contrast agent (Sonovue®) administration. Dedicated software was used to ...

The effect of some drug properties (wettability and particle size distribution) on granule properties (mean particle size, particle size distribution, sphericity, and granule strength) were investigated in a high (>97%) drug-loading formulation using fluidized bed rotor granulation. Three drugs: acetaminophen (APAP); ibuprofen (IBU); and ethenzamide (ETZ) were used as model drugs based on their...

The influence of particles properties on biofilm structure, reactor performance, and energy consumption for denitrifying fluidized bed bioreactors (DFBBRs) using maxi-blast plastic (MX), multi-blast plastic (MB), natural zeolite (NZ), and lava rock (LR) was investigated. The work showed that the particles with sphericity of 0.9 (MB and NZ) maintained a fluffy protruding biofilm and achieved sli...

Building upon the work of Chen et al. (2010), this paper proposes a test for sphericity of the variance-covariance matrix in a fixed effects panel data regression model without the normality assumption on the disturbances.

The evolution of the 3D Fe-rich phases Al–7.0Si–1.2Fe alloys with different Mn contents was visualized and characterized using synchrotron X-ray computed tomography, effect typical morphologies on fracture behavior during tensile testing analyzed. results showed that phase changed from platelet-like ?-Al5FeSi into ?-Al15(FeMn)3Si2 various after addition Mn. not only significantly reduced volume...

Data from repeated measures experiments are usually analyzed with conventional ANOVA. Three well-known problems with ANOVA are the sphericity assumption, the design effect (sampling hierarchy), and the requirement for complete designs and data sets. This tutorial explains and demonstrates multi-level modeling (MLM) as an alternative analysis tool for repeated measures data. MLM allows us to est...