background: health-related quality-of-life (hr-qol) may be affected by various factors including injury-related characteristics among individuals with spinal cord injury (sci). however, the impact of the influence of these variables has not yet been fully described in iranian population. here, we assessed the relationships between injury-related characteristics and hr-qol among iranian people w...

background in recent decades, the incidence of spinal cord injuries has increased. in a systemic review on epidemiology of traumatic spinal cord injury in developing countries reported 25.5/million cases per year. objectives to assess the quality of life (qol) of the veterans among iran-iraq war with chronic spinal cord injuries (sci) and to evaluate long-term impressions of sci on their qualit...

conclusions the results indicate that a decrease in health status level of veterans, physically and mentally, can affect the health-related qol of their caregiving spouses. results the mean age and standard deviation of veterans and their spouses were 48.5 ± 5.9 and 44.8 ± 7.2, respectively and their number of children ranged between 0-6. our data analysis showed that there was a significant di...

Summary: Background: Patients with spinal cord injury (SCI) usually have permanent and often devastating neurologic deficits and disability and pain (1). According to the National Institutes of Health, "among neurological disorders, the cost to society of automotive SCI is exceeded only by the cost of mental retardation"(2). Neurogenic pain constitutes one of the enigmatic clinical sy...

Spinal cord injury induces the disruption of blood-spinal cord barrier and triggers a complex array of tissue responses, including endoplasmic reticulum (ER) stress and autophagy. However, the roles of ER stress and autophagy in blood-spinal cord barrier disruption have not been discussed in acute spinal cord trauma. In the present study, we respectively detected the roles of ER stress and auto...

conclusions this case report supports the beneficial role of erythropoietin in function, maintenance, and recovery of neurons. erythropoietin is a double-edge sword, as long-term erythropoietin therapy has some complications, like thromboembolism and stroke. recent studies suggested that erythropoietin should be given as single high dose to exert a rapid neuro-protective effect with minimal hem...

cell therapy is known as one of the most promising curative interventions in the spinal cord injury (sci). selection of an appropriate route to transplant the stem cells is very important. principally, four different injection routes have been used in animal experiments. 1. intramedullary route: this route is known as a classic method for transplantation of stem cells. in this method, the stem ...

stem cell therapy can be useful for spinal cord injury (sci). induced pluripotent stem cells (ipscs) are generated by reprogramming mature, fully differentiated cells into a pluripotent state. the ability to generate pluripotent cells from adult somatic cells without the need for an embryo was a major development in stem cell biology. ipscs were established from mouse fibroblasts and demonstrat...